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Research Plans Computational Neuroscience Jutta Kretzberg University of Antwerp 7.6.2007

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Presentation on theme: "Research Plans Computational Neuroscience Jutta Kretzberg University of Antwerp 7.6.2007"— Presentation transcript:

1 Research Plans Computational Neuroscience Jutta Kretzberg University of Antwerp 7.6.2007 http://www.uni-oldenburg.de/sinnesphysiologie/en/

2 Important response features Individual cells Cell ensembles Origin of neuronal responses Cellular properties Network interactions Reliability of responses time Central question: Neural coding

3 Vertebrate retina Currently used systems Leech nervous system

4 Latency-based retinal coding of visual stimuli during eye movements Retinal ensemble coding under dynamic conditions Mechanisms of retinal coding for global image movement Multi-electrode recordings and data analysis (Bayesian reconstruction, metric-based clustering, information-theoretic methods) Retinal coding - current projects

5 Simulations based on physiological data (networks of simplified models, multi-compartment models) Retinal coding - future projects Retinal network interactionsHorizontal cell physiology Kolb 1974

6 200 Leech CNS - current project Electrophysiology and Simulations (intracellular recordings, multi-compartment models) Influence of ion channel distribution on spike activity ExperimentSimulation

7 Leech CNS - future projects Local bend network Electrophysiology and Simulations (intracellular recordings, multi-compartment & network models) Encoding of touch stimuli Interaction of inputs to interneurons Sources of variability Network interactions between sensor cells Role of electrical connections in the network

8 Common interests with TNB group Neural codingOrigin of response dynamics Methods Single cells Relevant response features Cell-intrinsic anatomy and biophysics Intracellular & patch clamp recordings Multi-compartment models Spike time analysis Multiple cells Correlations between responses Network interactions Multi-electrode recordings Network models Correlation analysis

9 New impulses Sensory coding Well-defined input and output Direct link to behavior Analysis of retinal network Multi-electrode recordings Several data analysis methods Analysis of leech network Easily approachable microcircuit Close sensory-motor interaction Similar questions and methods: Comparison of different systems

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