1. Chapter 11 Cell Communication

2. Question? u How do cells communicate?

3. Why do cells communicate?

4. Cell Communication

5. Cell Signaling (C.S.) u Is a relatively “new” topic in Biology and AP Biology. u Appears to answer many questions in medicine. u Is a topic you’ll be hearing more about in your future.

6. Stages of C.S.

7. Reception

8. Transduction

9. Response

10. Reception

11. Direct Contact

15. Signal Molecules

17. Receptor Molecules

19. G-protein linked

21. G-protein

24. G-protein linked receptors

27. Tyrosine-Kinase Receptors

28. Mechanism

30. Intracellular Proteins

31. Tyrosine-Kinase Receptors

32. Ion-channel Receptors

35. Intracellular Signals

38. Comment

39. Signal-Transduction Pathways

41. Protein Phosphorylation

42. Protein Kinase

43. Amplification

45. Secondary Messengers

47. cAMP

49. Calcium Ions

52. Inositol Trisphosphate (IP 3 )

53. Start here Or Start here

56. Animation Link u http://entochem.tamu.edu/G- Protein/index.html http://entochem.tamu.edu/G- Protein/index.html

57. Cellular Responses

58. Cytoplasmic Regulation

59. Transcription Regulation

61. Question u If liver and heart cells both are exposed to ligands, why does one respond and the other not?

62. Alternate explanation

63. Comment u Chapter focused only on activating signals. There are also inactivation mechanisms to stop signals.

64. Summary u Don’t get bogged down in details in this chapter. Use the KISS principle. u Know - 3 stages of cell signaling. u Know - At least one example of a receptor and how it works (in detail).