1. HLA antigen APC cell LFA-1 signaling T cell receptor LFA-1 Ser 1140 intracellular signaling

2. HLA antigen APC cell Talin Calpain PtdIns(4,5)P 2 Talin Head LFA-1 signaling LFA-1 Ser 1140 T cell intracellular signaling T cell receptor

3. HLA antigen APC cell LFA-1 increased affinity for ICAM-1 PKC LFA-1 signaling Ser 1140 T cell Thr 758 intracellular signaling T cell receptor

4. HLA antigen APC cell increased affinity for ICAM-1 14-3-3 ? GEF actin reorganization LFA-1 signaling LFA-1 Ser 1140 T cell Thr 758 Rac1 GDP GTP Rac1 LFA-1 clustering intracellular signaling T cell receptor