1. Yeast - why it simply has a lot to say about human disease

2. Genetic mutations identified in human disorders

3. A richness of data allows yeast to tell a multi-dimensional story Zhu, et al. (2012), Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. PLoS Biology metabolites genes genes w/cis-eQTLs Leu3p binding sites

4. Human connections into SGD Homology & Disease X Functional Complementation Phenotypes & Orthology Literature Drug Interactions

5. Searchable Connections gene name

6. Searchable Connections yeast gene

7. Searchable Connections human gene

8. disorder Searchable Connections

9. A real and present connection

10. NGLY1 SGD’s Advanced Search

11. A real and present connection yeast PNG1 phenotypes function pathways literature protein properties genetic interactions NGLY1 SGD’s Advanced Search

12. Connection start points Human genes Yeast homologs Function known, human homologs Yeast genes 4500 genes 1340 diseases 2750 genes

13. SGD: Powering Connections