1. University of Michigan: UMi2b2 Cohort Training An introduction to UMi2b2 Cohort June 2, 2011

2.  Throughout this course you will learn how to:  Log into UMi2b2 Cohort  Navigate the User Interface  Identify Terminology Subject Areas  Create Sample Cohort Queries  Save Cohort Queries  Recall Saved Cohort Queries UMi2b2 Cohort Training Goals

3.  i2b2 - Informatics for Integrating Biology & the Bedside  An advanced cohort discovery and analysis tool  NIH-funded National Center for Biomedical Computing based at Partners Health Care System  Adopted by the CTSA network What is i2b2? source: https://www.i2b2.org/

4.  Easier to use interface  Increased number of health system clinical data sources  Becoming the standard for cohort discovery at other leading research institutions  Recently Approved as a pre-IRB, pre-grant cohort discovery tool UMi2b2 Cohort vs. iFeasible

5.  Enable researchers to more effectively identify potential research subjects for clinical trials.  Advance clinical trial recruitment and improve health care research at the University of Michigan. Our Priorities

6. Who uses i2b2? Boston University Case Western Reserve University Weill Cornell Medical College Duke University Harvard Medical School Kaiser Permanente Health Medical College of Wisconsin The Ohio State University Oregon Health & Science University Mayo Clinic Medical University of South Carolina Northwestern University Tufts Medical Center University of Alabama at Birmingham University of California, Davis University of California, San Francisco University of Chicago University of Cincinnati University of Massachusetts Medical School University of Michigan University of Pennsylvania University of Pittsburgh University of Rochester School of Medicine and Dentistry University of Texas Health Science Center at Houston University of Texas Health Science Center at San Antonio University of Texas Southwestern Medical Center at Dallas University of Utah University of Washington University of Wisconsin – Madison

7.  Supported by the MCIT-CRHIX team  Branded UMi2b2 Cohort  Contains over 600 million rows of searchable data  Currently accepting and training new users i2b2 @ UM

8.  Where does the i2b2 data come from?  Health System Data Warehouse (HSDW)  HealthQuest – Patient Management  TSI - Profee Billing  PathNet – Lab Results  Clinical Data Respository (CDR) i.e. CareWeb  Medications UMi2b2 Cohort (the details)

9.  UMi2b2 Cohort can compile patient count data based upon pre-defined search criteria including, but not limited to:  Age at Encounter  Age at Lab Order  Patient Demographics  ICD-9 Diagnoses & Procedures  CPT4 Procedures (Outpatient – CPT4)  Lab Results (LIS-LOINC)  Inpatient & Outpatient Medication Orders  Medications (Outpatient by Formulation)  CareWeb PSL (Problem Summary List) Medical Orders How does UMi2b2 Cohort work?

10. The Interface:

11.  Supported browsers include: Firefox, Internet Explorer & Safari.  Login URL: https://i2b2.med.umich.eduhttps://i2b2.med.umich.edu  User ID: your unique name  Password: your Level-2 password Logging In:

12.  User Identification:  Links:  Tabbed Panes:  Zoom Control:  Options  Tailored for each area  Increased Capabilities The UMi2b2 Cohort Interface:

13.  Find Patients: returns user to Home Screen  Analysis Tools: currently unavailable  Message Log: record of XML (debugging)  Help: redirects user to UMi2b2 Cohort support site  About: provides information about the current UMi2b2 Cohort Web Client version  Logout: exits the current session “Links” Overview:

14.  Allows for drag & drop of query concepts  Provides hierarchical display of related search terms “Navigate Terms” Tab & Options  Control the number of rows to display  Any search term concepts set as invisible will be shown  Show search concept synonyms

15.  Search by Names:  Words & Word Fragments  Exact Phrases  Search by Codes:  Select coding system  Enter appropriate code “Find Terms” Tab

16.  Workspace to build queries  Combine search concepts to assemble and refine queries  Groups can further be defined by:  Date ranges  Number of occurrences  Exclusion of criteria  Run Query  New Query “Query Tool”

17.  Options: controls query timeout value  Status: displays progress of queries being run and record of query results Query Options & Status

18.  Provides a record of queries executed by the user  Displays either default or assigned names  Queries can be reused “Previous Queries” & Options  Controls total number of queries to display from query history  Manage query sort order:  Name  Creation Date

19.  Allows users to share queries with colleagues  Allows for local storage of queries:  Series of refined queries  Build template queries “Workplace”

20.  Assume that we would like to discover the number of diagnoses at the University of Michigan Health System of Appendicitis in adult male patients during 2010.  Log in: https://i2b2.med.umich.eduhttps://i2b2.med.umich.edu  Requires University-issued Level-2 user name and password and completion of MCIT-led UMi2b2 Cohort user training course. UMi2b2 Cohort Use Case

21.  Answers to Scenario # 1: 209 Patients  Research Scenario #2: Determine the number of patients with the following CPT codes during 2009:  21172, 21175, 21179 (28)  Research Scenario #3: Determine the number of patients with Sjogren’s (710.2) and Lung Disease (515) going back to January 2007. (180)  Research Scenario #4: Determine the number of patients with a diagnosis of Anorexia Nervosa (307.1) and Diabetes Mellitus (250) going back to January 2006. (8) Answers & More Practice:

22.  Visit the newly-released UMi2b2 Cohort web page at: http://www.michr.umich.edu/services/clinicalresearch/i2b2 http://www.michr.umich.edu/services/clinicalresearch/i2b2  Here you will find a number of resources including:  Comprehensive list of FAQs  Learning Resources  Security Information  Support Information  Link for Requesting an Account Additional Information:

23.  Confluence-based support page: https://wiki.umms.med.umich.edu/display/Mi2b2/i2b2+Sup port https://wiki.umms.med.umich.edu/display/Mi2b2/i2b2+Sup port  Follow us on Twitter: https://twitter.com/#!/UMi2b2https://twitter.com/#!/UMi2b2  E-mail our team:  MCIT-CRHIX-BIR-UMi2b2Cohort@med.umich.edu MCIT-CRHIX-BIR-UMi2b2Cohort@med.umich.edu Other UMi2b2 Cohort Resources:

24.  Your feedback is very important to us  We want to know what you think about the training:  We will be sending out a short training survey following the class  We’d also like to know how we can improve:  What did you like about the class?  What did you dislike about the class?  Did you encounter any issues?  Please send any follow-up comments to mcit-bir-crhix- UMi2b2Cohort@umich.edumcit-bir-crhix- UMi2b2Cohort@umich.edu Your Feedback

25. Questions?