1. Coccidiosis Poultry Vaccines
Akzo Nobel N.V. (Intervet)
British Technology Group U.S.A., Inc.
USDA
Enzon
Hoffmann-La Roche
Solvay & Cie, S.A.
Pfizer

2. Coccidiosis Poultry Vaccines
Akzo Nobel N.V. (Intervet)
British Technology Group U.S.A., Inc.
USDA
Enzon
Hoffmann-La Roche
Solvay & Cie, S.A.
Pfizer

3. Eimeria in Poultry Eimeria tenella Eimeria necatrix Eimeria acervulina
Eimeria maxima
Eimeria brunetti
Eimeria mivati
Eimeria mitus
Eimeria meleagrimitis
Eimeria adenoides

4. Coccidiosis Poultry Vaccines
Akzo Nobel N.V. (Intervet)
British Technology Group U.S.A., Inc.
USDA
Enzon
Hoffmann-La Roche
Solvay & Cie, S.A.
Pfizer

5. Eimeria in Poultry Eimeria tenella Eimeria necatrix Eimeria acervulina
Eimeria maxima
Eimeria brunetti
Eimeria mivati
Eimeria mitus
Eimeria meleagrimitis
Eimeria adenoides

6. Eimeria vaccines Akzo Nobel N.V.
Sporozoite proteins
Merozoite proteins
E. acervulina
E. tenella
200 kD
100 kD
50 kD
20 kD US US US US US US US US US US US

7. Life cycle of coccidia

8. Sporozoite of Eimeria ssp.

9. Invasion des Sporozoiten

10. Sporogonie und Merogonie

11. Eimeria tenella

12. Economic Impact of coccidiosis
US 300 Mio $ loss/year
(3 billion broilers estimate (6.741 in 1997)
US 100 Mio to 150 Mio/year
NovoPlant 150 to 250 Mio $ USA
15-30 Mio DM in BRD 1997 bei 750 Mio Produktion
Mio DM in EU 1996
1.0 to 2.0 cents/ kg
13 Mio Guilders in NL

13. Effectiveness of Vaccination against E. tenella
4 week old birds, 2.4 mg antigen, 75,000 oocysts, US Patent

14. Recombinant anticoccidial vaccine (US5635181 BTG)
Challenge with oocysts of E.tenella,
E.mitis, E.acervulina, E.maxima, E. brunetti
* 10 6 oocysts / g feces

15. Protection against E. acervulina infection
US Vermeulen et al.

16. MABs against sporozoite antigens can reduce rate of E
MABs against sporozoite antigens can reduce rate of E.tenella infection

17. Methods of Vaccination against Eimeria
Fowl pox virus
Yeast surface protein
Bacterial surface protein
Injection
Drinking water
Feed
US Schenkel et al.

18. Monoclonal Antibodies used for antigen screening