1. Current Status of Avian Influenza (H5N1) (Commonly referred to as the Bird Flu) Glen J. Arnold OSU Extension, Putnam County, Ottawa, Ohio; and Teresa Y. Morishita, DVM, PhD, Dipl. ACPV College of Veterinary Medicine, Western University of Health Sciences, Pomona, California

2. Avian Influenza  Influenza Type A  All subtypes can affect birds  Poultry disease  Waterfowl reservoirs

3. Avian Influenza Subtypes  Name based on surface proteins  Hemagglutinin proteins H5, H7 subtypes H5, H7 subtypes  Neuraminidase proteins N1 N1 AI

4. Avian Influenza  Signs Respiratory Tract Respiratory Tract SneezingSneezing Excess DischargesExcess Discharges Swollen SinusesSwollen Sinuses Digestive Tract Digestive Tract DiarrheaDiarrhea Neurological System Neurological System Twisted headsTwisted heads Uncoordinated gaitUncoordinated gait

5. Avian Influenza  Humans Respiratory Tract Respiratory Tract Flu-likeFlu-like Digestive Tract Digestive Tract DiarrheaDiarrhea

6. H5N1 Avian Influenza Timeline  1996: H5N1 from goose in Guangdong Province  1997: poultry farms and markets in Hong Kong; 6/18 human fatalities  2/03: 1/2 human fatality; travel to Fujian Province; 1/1 suspect

7. First Wave of H5N1 Influenza  Mid-03: H5N1 causes outbreaks, undetected and unreported  12/03: Two tigers and two leopards die of H5N1 avian influenza. FIRST CASE IN BIG CATS

8. First Wave of H5N1 Influenza  12/03:Korea  1/04: Vietnam, Japan, Thailand, Cambodia, Laos  2/04: Indonesia, China Human Cases: 8/12 Thailand;16/23 Vietnam; Cannot rule out limited human-to-human contact

9. Second Wave of H5N1 Influenza  6-7/04:China, Indonesia, Thailand, Vietnam  Possible role of wild birds  More lethal for mammals; fatal to waterfowl  7/04: Japan is disease- free  8/04: Malaysia; infections in pigs and cats; cat was previously considered resistant  9/04: Korea is disease- free  10/04: 147/441 tigers in Thailand; two eagles from Thailand imported into Brussels; domestic ducks as reservoirs Human Cases 4/5 Thailand; 4/4 Vietnam

10. Third Wave of H5N1 Influenza  12/04: Indonesia, Thailand, Vietnam; possibly Cambodia and Laos  1/05: Malaysia is disease-free  4/05: 6,345 wild birds in central China  6/05: China’s Xinjiang region  7/05: 4/05 outbreak from new variant; virus transmitted among geese and may spread via migratory routes; civets infected; Russian poultry and wild birds  8/05: Kazakhstan poultry and wild birds; Tibet; Mongolia  10/05: Turkey; Romania; songbirds from China smuggled into Taiwan; imported parrot in United Kingdom; China’s Anhui and Hunan Province; Croatia wild birds; Macedonia Human Cases human-to-human transmission 21/64 Vietnam; 4/4 Cambodia; Thailand and Indonesia

11. Third Wave of H5N1 Influenza  11/05: Chinese poultry  12/05: Ukraine; Kuwait flamingo (first in Gulf Region)  1/06: Human cases in Turkey and Iraq

12. The Wave Continues  2-3/06: Iraq; poultry in Nigeria (first in Africa); wild birds (swans) in Azerbaijan, Bulgaria, Greece, Italy, Slovenia, Iran, Austria, Germany; poultry and zoo birds in Eqypt; poultry in India; France; wild birds in Denmark and Spain, UK

13. Patterns  Spreading over land mass  Need for expedient diagnosis  Poultry involved  Wild birds and migration routes

14. Areas of Concerns  Migratory Birds reservoirs reservoirs overlap of summer breeding areas overlap of summer breeding areas

15. Areas of Concerns  Illegal Commerce songbirdssongbirds fighting chickensfighting chickens raw and undercooked productsraw and undercooked products Duck Soup (Czarnina) "This is an old Polish recipe that was used at Easter time. This recipe is traditionally served with home made noodles. If desired the fruit can be removed, leaving broth to serve with noodle. If you do not know where to purchase a duck, contact a local farmer or butcher. If you prepare your own poultry be sure to add 1/2 cup vinegar to duck blood to prevent coagulation." Original recipe yield: 12 servings.

16. Areas of Concerns  Commerce live bird marketslive bird markets transport of birds, mammals?transport of birds, mammals?

17. Stopping a World Pandemic  Human-to-Human Transmission  Education  Expedient Diagnosis, Isolation, Quarantine