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Immune Risk Phenotype Dr. Gabriele Rumi. Effect of the genetic background and aging on the immune system.

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Presentation on theme: "Immune Risk Phenotype Dr. Gabriele Rumi. Effect of the genetic background and aging on the immune system."— Presentation transcript:

1 Immune Risk Phenotype Dr. Gabriele Rumi

2 Effect of the genetic background and aging on the immune system

3 Interplay between the IRP, low grade inflammation, and cognitive impairment in mortality

4 From the clinical perspective, the percentage of the cytotoxic CD8+ CD28– T cells reflected a more severe course of disease, as it correlated with distinct movement restrictions, as well as the metrology score summarizing cervical rotation (in sitting position), chin-to-jugulum distance, thoracic Schober, chest expansion, and fingers- to-floor distance (P = 0.032). Schirmer M, Goldberger C, Würzner R, Duftner C, Pfeiffer KP, Clausen J,Neumayr G, Falkenbach A. Arthritis Res. 2002;4(1):71-6. Epub 2001 Oct 16. PubMed Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitis.

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7 Immunological biomarkers of ageing in man changes in both innate and adaptive immunity are associated with health and longevity


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