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High resolution clinical phenotype: Demographics Socio-Economic status Birth History Social History Family History Pre-kidney disease H. Kidney disease.

Published byErick Ward Modified over 9 years ago

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Presentation on theme: "High resolution clinical phenotype: Demographics Socio-Economic status Birth History Social History Family History Pre-kidney disease H. Kidney disease."— Presentation transcript:

1 High resolution clinical phenotype: Demographics Socio-Economic status Birth History Social History Family History Pre-kidney disease H. Kidney disease H. Medication H. Clinical Symptoms Physical Exam Quality of Live Patient recorded outcomes (PROMIS) Adverse Events Histopathology (local and digital repository) 1 4-6 monthly visits, 473 parameters captured in 1053 data fields

2 Glass slides are scanned using Aperio ScanScope OS Data analysis Kidney bx slide Scoring process on annotated images Annotator Scoring process on annotated images Reader #1 Reader #2 L. Barisoni, S.Hewitt, J. Kopp

3 Comprehensive Sample Procurement DNA: – blood, kidney, urine RNA: – Blood, kidney, urine Serum Plasma – EDTA, NaHep, NaCitrate Urine – Spot / 24h – Native, NaAz, Protease In. – Urine sediment Funded: Targeted Sequencing GWAS Nephron-segment specific Transcriptome Digital Path incl. glomerular Morphometry Options to capture genome wide profiles along genotype – phenotype continuum 3

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