1. Progressione centri attivati vs pz. trattati

2. Time delay (median min) Italy All centres Onset to treating hospital/door time 68.075.0 Door to imaging study time 30.024.0 Door to treatment/needle time 86.065.0 Onset to treatment/needle time 165.0151.0 Time logistics

3. VariablesItalyAll centres Age6970 Male56%54% Female44%46% NIHSS Median11.010.0 NIHSS 0-732%34% NIHSS 8-1435%33% NIHSS >1534%33% Current smoker17%16% Previous smoker14%11% Atrial fibrillation18%21% Congestive heart failiure7%8% Systolic150.0153.0 Diastolic81.083.0 Demographic and baseline data

4. Clinical outcome at 3 months mRS 0-2Recovered patients Proportion recovered Lower Confidenc e Limit Upper Confidence Limit Italy971/159461,358,963,7 All centers3033/528658,35759,7 mRS 0-1 Italy781/159449,346,951,8 All centers2262/528643,542,244,9 MortalityDead within 3 months Proportion Dead Lower Confidenc e Limit Upper Confidence Limit Italy174/169410,38,911,8 All centers760/611012,411,613,3

5. Symptomatic intra-cranial hemorrhage SICH definition SICH patients Proportion SICH Lower Confidence Limit Upper Confidence Limit SITS-MOST Italy36/18961,91,42,6 All centers90/61231,51,21,8 ECASS Italy74/182843,25,1 All centers263/524254,55,6 NINDS Italy123/18286,75,78 All centers367/524276,37,7

6. Clinical outcome at 3-months (bNIHSS≥10; median 16) mRS 0-2N° of patients ProportionLower Confidenc e Limit Upper Confidenc e Limit Italy335/83440,537,243,8 All centers1055/276238,83740,6 mRS 0-1 Italy233/83428,125,231,3 All centers713/276226,224,627,9 MortalityDead within 3 months Proportion Dead Lower Confidenc e Limit Upper Confidenc e Limit Italy149/90716,414,219 All centers622/329018,917,620,3

7. Quanti pazienti dovremmo trattare? ~50% non trattabili16.000 ≤ 4.5 h 50% ~ 65.000 ~ 16.000 ≤ 3 h 30% ≤ 4.5 h 50% ~ 5.000 ~ 8.000 ~ 1.200 ~ 2.000 Range ~ 10.000 – 18.000 pz./anno ≤ 3 h 30% ~ 40.000 Trattabili con tPA per RCP ~ 25% ~ 10.000 Nuovi casi 134.000 Totale167.000Recidive33.000 Incidenza Ictus ischemico in Italia 30% 19.500 2.40021.900 3.174/21.900 = 14.5%