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Particle Based Drug Delivery Systems References LANGER, R.S. & PEPPAS, N.A. (1981) Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials. 2, 201-214. Week 6
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Solvent Casting Method
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POLYMER-DCM SOLUTION ADD TO PVA IN WATER & MIX SECONDARY EMULSION (W/O/W) SOLVENT EVAPORATION FILTRATION AND DRYING PRIMARY EMULSION (W/O) ULTRA SONICATION PROTEIN SOLUTION Double Emulsion Method
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Inlet temperature Polymer concentration Pump feed rate Aspirator ratio Compressed air flow rate Drug loadings Spray Dried Microspheres
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Microsphere surface morphology using different polymer solution concentrations AB D C F.J. Wang and C.H. Wang, “Sustained Release of Etanidazole from Spray Dried Microspheres Prepared by Non-halogenated Solvents”, J. Controlled Release, 81 263-280 (2002).
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Degradation of microspheres PLGA 65:35 1 month PLGA 50:50 1 month PLGA 85:15 3 month PDLA 3 month F.J. Wang, T.K.Y. Lee and C.H. Wang, “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555-3566 (2002)..
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Modulation of release by PEG small discs (diameter = 5mm, thickness =1mm) large discs (diameter =13mm, thickness = 1mm ) F.J. Wang, T.K.Y. Lee and C.H. Wang, “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555-3566 (2002).
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