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PRINCIPLES OF COMPOUNDING Terrick Andey College of Pharmacy & Pharmaceutical Sciences Florida A&M University February 2013
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SOLUTIONS –AQUEOUS SOLUTIONS Definition: a homogeneous mixture of dissolved solids, liquids, or gases (solute) in a liquid Molecules of the solute are dispersed among molecules of the solvent Solvent is typically water Classes: Water, Aromatic Water, Solutions, Douches, Enemas, Nasal solutions, Otic solutions, and Irrigation solutions
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SOLUTIONS - Water Major ingredient is water Used as vehicle and solvent for flavoring or medicinal agents Also used for preparing parenterals, irrigations, or inhalations U.S.P. defines many types of water including: Purified Water Water for Injection Sterile Purified Water Sterile Water for Injection Sterile Bacteriostatic Water for Injection Sterile Water for Inhalation Sterile Water for Irrigation
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However, there are two basic types of water preparation; Water for Injection and Purified Water They differ in the fact that Water for Injection has stricter bacterial count standards and must also Pass the bacterial endotoxin test
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SOLUTIONS – Aromatic Waters Also known as Medicated waters Characterics: clear, saturated aqueous solutions of volatile oils or other aromatic or volatile substances Their odor and tastes are similar to the volatile substances from which they are prepared Uses: flavored or perfumed vehicles
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SOLUTIONS – Aromatic Waters Preparation: Distillation Solution Incorporation of volatile oil in talc or pulped filter paper, adding purified water, agitating and filtering Examples: Peppermint water U.S.P. Camphor water N.F. Dill water Cinnamon water Caraway water Anise water
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SOLUTIONS – Aromatic Waters PEPPERMINT WATER U.S.P. R x : Peppermint oil2 ml Talc15 gm Purified water q.s. ad1000 ml Procedure: 1.Mix thoroughly talc with peppermint oil in a glass mortar 2.Remove the mixture from the motar to a calibrated Erlenmeyer flask 3.Add 100 ml purified water and shake periodically for 10 minutes 4.Filter; return first portion of filtrate (in order to obtain clear products) 5.Make up to volume with Purified water
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SOLUTIONS – Solutions Definition: a liquid prepn. containing one or more soluble chemical substances dissolved in water Use for specific therapeutic effect of the solute Preparation: Simple solutions: dissolving solute in solvent E.g.: Calcium hydroxide topical solution (Lime water), Sodium phosphates oral solution, Strong iodine solution
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SOLUTIONS – Solutions STRONG IODINE SOLUTION U.S.P. R x : Iodine 50 gm Potassium iodide100 gm Purified water, q.s. ad to100o ml Procedure: 1.Dissolve powdered iodine and potassium iodide in a glass mortar with about 800 ml of purified water 2.Transfer to a graduated cylinder 3.Add sufficient purified water to make up to 1000 ml
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SOLUTIONS – Douches Definition: an aqueous solution directed into a cavity or a part of the body Uses: cleansing agent or antiseptic E.g.: Eye douche, Pharyngeal douche, Nasal douche, Vaginal douche
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SOLUTIONS – Enemas Definition: Rectal injections used to evacuate the bowel, for systemic absorption, or for local action Classified as Evacuation enemas Retention enemas E.g.: Enema of Soap BPC 1963 Fleet enema Sulfasalazine rectal enema Barium sulfate enema
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SOLUTIONS – Nasal solutions Definition: Aqueous solutions intended for administration into nasal passages Dosage my be in the form or drops or sprays Must be isotonic with nasal secretions, with pH around 5.5-6.5 E.g.: Ephedrine sulfate U.S.P. Oxytocin nasal solution U.S.P.
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SOLUTIONS – Nasal solutions Ephedrine sulfate R x : Ephedrine HCl 0.5 gm Chlorobutanol0.5 gm Sodium chloride0.5 gm Purified water q.s.100 ml
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SOLUTIONS – Otic solutions Preparations intended for topical application in the ear Solvent is typically water or glycerin E.g.: Antipyrine and Benzocaine Otic Solution U.S.P. Neomycin Sulfate Otic Solution Polymyxin B Sulfate Otic Solution
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SOLUTIONS – Irrigation solutions Solutions used to perfuse or wash surgical wounds, incisions and body tissues Must be sterile, free of particulate matter and free from pyrogens Solvent is Water for Injection U.S.P. E.g.: Acetic acid irrigation U.S.P. (bladder) Aminoacetic acid irrigation U.S.P. (urethral surgery) Sodium chloride irrigation U.S.P.
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