1. Michael Chang (CEO) Ashok Ilankovan (CTO) Stephanie Pan (CMO) Patric Prado (COO) Alyssa Rios (CFO)

2. Patric Prado (COO/CRO) Ashok Ilankovan (CTO) Stephanie Pan (CMO) Alyssa Rios (CFO) Michael Chang (CEO)

3. What is Spinal Muscular Atrophy (SMA)? Genetic disease Attacks motor neurons in spinal cord Leads to muscle weakness and atrophy #1 genetic killer of children < age 2 (95% mortality) SMA type II ~ age 20 = 77%

4. Why design for SMA? Recent breakthroughs in research –SMN1 and SMN2 genes –NIH and NINDS massive funding –Research (JHU, Columbia, MIT, Stanford) Lots of new therapy treatments BUT…. Current evaluations are subjective, inaccurate, and insensitive. Clinicians Need: Robust and quantitative motion capture and analysis system

5. Constraints and Specifications ROBUSTNESS ERGONOMICS SAFETY RELIABILITY EASE OF USE / CONVENIENCE COST Variety of Patients Intentional Movements Limited Weight Natural Movements Constant arm support Repeatability Not overly sensitive Calibration Minimal External Cables Portable Minimal Training Balance Cost and Necessity Max Cost: Gaming Console Reduce Friction

6. Available Products SMArtView Inertial sensor Accelerometer based system Measures accelerations in 2D Price: > $2000 Visualeyez Active LED markers Optical based system Tracks motion of markers ShapeSensor Optical Sensor Fiber optic based system Measures bends & twists Price: >$5000 Price: varies

7. Related Products Air Hockey Table Air nozzles Floats objects on air Requires air compressor Price: $200 - $1000 Ball Transfer Plate Ball bearing rollers Provides a low friction platform Requires Lubrication Price: $100 – 300 Sling Strap Supports an injured arm Provides support by loading on another object Price: ~ $10 - 30

8. Related Products Optical Mouse CMOS sensor Based on camera technology Tracks 2D motion on a surface Price: < $10 Laser Gun Laser Transmitter/ Detector Based on transmit/receive time Measures velocity Price: ~ $500 Security Sensor IR Sensor Based on detecting IR emitted from humans Triggers an alarm Price: ~ $30

9. Idea 1

11. Idea 2

13. Idea 3

15. In a Nutshell… SMA is a deadly genetic disease Many new therapies coming out Need for a robust, quantitative motion capture and analysis system Current devices are either very advanced or too simple We propose: –a device to capture & evaluate 2D movements on frictionless, horizontal plane

16. Acknowledgements Elisa Konofagou, PhD Assistant Professor of Biomed. Eng. Columbia University Petra Kaufmann, MD Assistant Professor of Neurology Associate Director, Pediatric MDA Neuromuscular Clinic Elizabeth Hillman, PhD Assistant Professor of Biomed. Eng. Columbia University Keith Yeager Senior Staff Associate, Lab Manager Columbia University Jacqueline Montes Clinical Coordinator, Physical Therapist Pediatric MDA Neuromuscular Clinic Viktor Gamarnik Columbia University Alumnus Benjamin Koo Columbia University Alumnus Barclay Morrison, PhD Associate Professor of Biomed. Eng. Columbia University

17. Questions?