1. ANTIMUTAGENS in food

2. FOOD Foods are comlex mixtures containing both carcinogenic and anticarcinogenic substances. It is our choice – HEALTHY x NOT HEALTHY Prevention against cancer - ANTIMUTAGENS

3. Carcinogenesis Carcinogenesis: TWO STAGE PROCESs a) Initiation b) Promotion Inhibitors of mutagenesis = inhibitors of carcinegenesis

4. Antimutagens REDUCE NUMBER OF MUTATIONS Clasification: a) Desmutagens – they inactivate mutagens b) Bioantimutagens – reduce effect of mutagens Antioxidants „catch free radicals“

5. ASCORBIC ACID Water soluble The strongest antioxidant in body Cofactor of many enzymes dopamin - andrenalin

6. VITAMIN E It contains 8 substances (90%  -tokoferol). Fat soluble – inhibition of oxidation of unsaturated fatty acids. The richest natural source- plant oil

7.  - Karotene Lipid soluble pigment Enzymatically hydrolyzed – Vitamin A Antioxidant – fat stores and lipid membranes Treatment of some genetic diseases

8. SULFIDES Diallyl sulfide, diallyl disulfide – garlic React with nirosoamines Reduce level of LDL cholesterol and triacylgycerols

9. Glutathion Tripeptide Reducing agent, soluble in cellular plasmas Defence against toxic compounds (aflatoxin….)

10. Selenium Toxic x antimutagens, antioxidant Mechanism not clearly defined, depends on concetration PRECISE (Prevention of Cancer through Intervation with Selenium)

11. FLAVONOIDS Large group of substances Antioxidants, antimutagens, regulation of cholesterol

12. CATECHINS Up to 30% weight of dry tea 1. green tea, 2. white tea, 3. black tea The effect depends on preparation

13. What have I forgotten..? I know, that there many other antimutagens I haven´t talked about. Magnesium, Unsaturated fatty acids, glukosinates …etc. I hope they will excuse me..;-)

14. + AND THAT IS ALL THANK YOU FOR YOUR ATTENTION …