1. Gerard Kelly MD MEd FRCS (ORL-HNS) FRCS (Ed) ENT surgeon, Moor Allerton Golf Club 15 th May2014 ENT The Leeds Teaching Hospitals NHS Trust managing common nasal conditions

2. Back to Medical School group of GP's managing common nasal conditions to include  rhinitis o making the correct diagnosis o practical treatment  polyps o why should we worry about unilateral polyps  nose bleed  anything else you thinks important and practical

3. aims improve our understanding of nose conditions discuss some example cases formulate management plans for nasal disease

4. objectives list symptoms to be elicited in nasal conditions list ways on nasal examination discuss the evidence base in treating sinusitis describe a nasal cautery technique council a patient on sinus surgery list differential in nasal lesions list the presentation of a nasal malignancy recognise nasal sepal deviation list aetiologies in septal perforation recognise and manage nasal polyps

5. first though... history and examination in ENT

6. history ears otorrhoea otalgia itch hearing tinnitus balance noses nasal obstruction rhinorrhoea facial pain smell epistaxis post nasal drip throats dysphagia dysphonia odynophagia pain neck lumps weight loss

7. history ears otorrhoea otalgia itch hearing tinnitus balance noses nasal obstruction rhinorrhoea facial pain smell epistaxis post nasal drip throats dysphagia dysphonia odynophagia pain neck lumps weight loss

8. examination of the nose

9. examination

10. examination with auriscope

11. rhinosinusitis

12. sinusitis sinusitis

13. rhinitis rhinosinusitis

14. theories of rhinosinusitis

15. classification of rhinosinusitis

16. Non-allergic Rhinitis Allergic Rhinitis UK/FF/0108/11 April 2011

17. Allergic Rhinitis UK/FF/0108/11 April 2011

18. Allergic Rhinitis Epidemiology Allergic rhinitis is the most common form of non- infectious rhinitis At least 500 million individuals world-wide have allergic rhinitis and it is one of the most common reasons for attendance with a primary care practitioner Almost 30% of adults and 40% of children are affected World-wide the prevalence of allergic rhinitis continues to increase UK/FF/0108/11 April 2011 References 1.Bousquet J et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update. Allergy 2008;63 Suppl 86:8-160 2.Wallace DC et. J Allergy Clin Immunol 2008; 122: S1-84

19. Prevalence of clinically confirmed allergic rhinitis in Europe Reference: Bauchau V et al. Eur Respir J 2004; 24: 758-764 UK/FF/0108/11 April 2011

20. Clinical Diagnosis Nasal discharge Blockage Sneeze / itch } Rhinitis definition 1 2 or more symptoms for > 1 hour on most days Allergic Rhinitis Non-Allergic Rhinitis (Infection/structural abnormality/ vasomotor/primary disease ) History Examination Investigations UK/FF/0108/11 April 2011 Reference: 1. Bousquet J et al. Allergy 2008;63 Suppl 86:8-160

21. Clinical symptoms of allergic rhinitis primary clinical manifestations congestion rhinorrhoea itching sneezing secondary clinical effects lethargy malaise UK/FF/0108/11 April 2011

22. IMPAIRED WELL BEING DISRUPTED SLEEP LETHARGY DAILY ACTIVITIES IMPAIRED LEARNING & COGNITIVE FUNCTIONS DISTURBED REDUCED WORK & SCHOOL PRODUCTIVITY Canonica GW et al. Allergy 2007: 62 (Suppl. 85): 17-25 UK/FF/0108/11 April 2011 Social and economic impact of allergic rhinitis

23. Investigations Skin prick testing (SPT) Panel of common aeroallergens + allergen identified as relevant in history Serum allergic specific-IgE In cases where SPT is negative or SPT cannot be performed Rhinoscopy Indication Atypical features (i.e. one sided obstruction) present or multiple pathology suspected Classic findings Pale oedematous mucosa Congestion Mucus secretion UK/FF/0108/11 April 2011

24. Investigations Skin prick testing (SPT) Panel of common aeroallergens + allergen identified as relevant in history Serum allergic specific-IgE In cases where SPT is negative or SPT cannot be performed Rhinoscopy Indication Atypical features (i.e. one sided obstruction) present or multiple pathology suspected Classic findings Pale oedematous mucosa Congestion Mucus secretion UK/FF/0108/11 April 2011

25. Investigations Skin prick testing (SPT) Panel of common aeroallergens + allergen identified as relevant in history Serum allergic specific-IgE In cases where SPT is negative or SPT cannot be performed Rhinoscopy Indication Atypical features (i.e. one sided obstruction) present or multiple pathology suspected Classic findings Pale oedematous mucosa Congestion Mucus secretion UK/FF/0108/11 April 2011

26. Allergic Rhinitis Classification BSACI Guidelines Seasonal (UK) Tree pollen (birch, plane, ash + hazel) Grass pollen (timothy, rye + cocksfoot) Weed pollen ( mugwort + nettle) Fungal spores ( Cladosporium spp, Alternaria spp + Aspergilus spp) Perennial (UK) House dust mite (Dermatophagoides pteronyssinus) + Animal Dander Occupational Flour, grain, latex, wood dust, detergents UK/FF/0108/11 April 2011 British society for allergy and clinical immunology

27. Bousquet J et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update. Allergy 2008;63 Suppl 86:8-160 UK/FF/0108/11 April 2011 Rhinitis Management

28. Diagnosis of allergic rhinitis Intermittent symptoms Mild oral antihistamine or intranasal antihistamine +/- decongestant or leukotriene antagonist Asthma? Moderate oral antihistamine or intranasal antihistamine +/- decongestant or topical nasal steroid or leukotriene antagonist or cromogycate consider

29. Diagnosis of allergic rhinitis Persistent symptoms Asthma? Mild oral antihistamine or intranasal antihistamine +/- decongestant or topical nasal steroid or leukotriene antagonist or cromogycate consider

30. Diagnosis of allergic rhinitis Persistent symptoms Asthma? Moderate severe topical nasal steroid oral antihistamine or leukotriene antagonist Review after 2 -4 weeks If better, step down and continue for > 1 month consider

31. Diagnosis of allergic rhinitis Persistent symptoms Asthma? Moderate severe topical nasal steroid oral antihistamine or leukotriene antagonist Review after 2 -4 weeks If not better, review diagnosis review compliance query infective / other cause increase nasal steroid ipratropium (rhinorrhoea) decongestant or oral steroid (blockage) consider

32. Diagnosis of allergic rhinitis Persistent symptoms Asthma? Moderate severe topical nasal steroid oral antihistamine or leukotriene antagonist Review after 2 -4 weeks If not better, review diagnosis review compliance query infective / other cause increase nasal steroid ipratropium (rhinorrhoea) decongestant or oral steroid (blockage) If not better, refer consider

33. Common co-morbidities: Asthma Approximately 80% of asthmatics have rhinitis Allergic rhinitis may precede asthma Rhinitis impairs asthma control Treatment of allergic rhinitis may improve asthma control Allergic Rhinitis and its Impact in Asthma (ARIA) promotes assessing everyone with allergic rhinitis for asthma UK/FF/0108/11 April 2011 References 1.Bousquet J et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update. Allergy 2008;63 Suppl 86:8-160 2.Wallace DC et. J Allergy Clin Immunol 2008; 122: S1-84

34. Common co-morbidities: Rhinoconjunctivitis Incidence Ocular symptoms are common Rhinoconjunctivitis symptoms have been reported in more than 75% of patients with seasonal allergic rhinitis Clinical significance Severely impairs QOL Often a forgotten aspect of care UK/FF/0108/11 April 2011 Reference 1. Wallace DC et al. J Allergy Clin Immunol 2008; 122: S1-84

35. rhinosinusitis

36. Allergen Avoidance Background Success of intervention measured by clinical improvement Strategy success influenced by individual host sensitivity to allergen Sensitivity differs betweens allergens Effectiveness Studies do not show consistent reduction in symptoms or medication requirements UK/FF/0108/11 April 2011 Reference: 1.Scadding GK et al. Clin Exp Allergy 2008; 38:19-42

37. rye grass

38. house dust mite

39. allergen avoidance mattress, pillow, duvet covers synthetic duvets, pillows avoid woollen blankets vacuum frequently avoid carpets, curtains keep clothing in cupboards keep animals out of bedrooms low relative humidity boil wash sheet, duvet covers

40. allergen avoidance

42. Fel d1

43. treatments UK/FF/0108/11 April 2011

44. Intranasal Steroids risks? UK/FF/0108/11 April 2011

45. Bioavailability of nasal steroids Bioavailability of nasal steroids References 1.Nasonex Summary of Product Characteristics. Date accessed April 2011 2.Kariyawasam H, Scadding G.Journal of Asthma and Allergy 2010: 3 19–28 3.Rhinocort Summary of Product Characteristics. Date accessed April 2011 4.Beconase Summary of Product Characteristics. Date accessed April 2011 UK/FF/0108/11 April 2011 Mometasone Fluticasone

46. epistaxis and cautery

47. Case

48. Epistaxis Naspetin ointment Vs Cautery and Naseptin ointment

49. theories of rhinosinusitis

51. investigation - sinus x ray Exposure to radiation poor sensitivity poor specificity

52. investigation - CT scan

53. nasal polyps

54. nasal polyps - treatment medical steroids surgical polypectomy

55. unilateral nasal discharge

56. child foreign bodyor neoplasm

57. unilateral nasal polyp

58. neoplasm benign or malignant

59. unilateral nasal polyp is it really unilateral?

60. unilateral nasal polyp neoplasm benign or malignant woodworking, metal, textile and leather industries

61. unilateral nasal polyp neoplasm benign or malignant watch for pain, eye involvement, tears, movement, facial sensation

62. unilateral nasal polyp neoplasm benign or malignant Nasal obstruction (36%), epistaxis (30%) & nasal discharge (21%) were the most common presentation

63. unilateral nasal polyp neoplasm benign or malignant inverted papilloma

64. nasal pain crusting

65. Case

66. Septal perforation - investigations FBCnormal ESR16 mm/hCRP<5.0 mg/l U&Enormalglucose5.0 mmol/l syphilisnegativeACEnegative ANCAnegative

67. Nasal septal perforation surgery trauma cocaine use infection post trauma, syphilis Wegener’s granulomatosis sarcoidosis idiopathic

68. objectives list symptoms to be elicited in nasal conditions list ways on nasal examination discuss the evidence base in treating sinusitis describe a nasal cautery technique council a patient on sinus surgery list differential in nasal lesions list the presentation of a nasal malignancy recognise nasal sepal deviation list aetiologies in septal perforation recognise and manage nasal polyps

69. Head Neck.Head Neck. 2013 Aug 30. doi: 10.1002/hed.23485. [Epub ahead of print] Sinonasal adenocarcinoma: A 16-year experience at a single institution. Bhayani MK Bhayani MK 1, Yilmaz T, Sweeney A, Calzada G, Roberts DB, Levine NB, Demonte F, Hanna EY, Kupferman ME.Yilmaz TSweeney ACalzada GRoberts DBLevine NBDemonte FHanna EYKupferman ME Author information Abstract BACKGROUND: Adenocarcinoma is a rare tumor of the sinonasal tract. The purpose of this study was to characterize a single institution's experience with this malignancy. METHODS: Retrospective review was performed of patients with adenocarcinoma of the sinonasal tract from 1993 to 2009. Demographic data, disease presentation, treatment, and survival rates were collected and evaluated. RESULTS: We identified 66 patients with sinonasal adenocarcinoma; 48 were men and 18 women. Average age at time of diagnosis was 57.1 years (range, 20-88 years), and median follow-up was 55.3 months (range, 1-238 months). The ethmoid sinus (38%) and nasal cavity (36%) were the most common sites of origin. Nasal obstruction (36%), epistaxis (30%), and nasal discharge (21%) were the most common presenting symptoms. Fifty-one percent of patients presented with T1 or T2 tumors. Surgery was the primary form of treatment in 81% of patients. Twenty-six percent of surgical patients underwent an endoscopic tumor resection. Adjuvant radiation was utilized in 50% of patients and chemotherapy in 10%. Recurrence was seen in 24 patients (37%): 29% recurred locally and 7.6% recurred distantly. The overall 5-year survival was 65.9%. Survival was decreased significantly in patients with T4 tumors (p <.05), high-grade histology (p <.05), and sphenoid sinus involvement (p <.05). Survival was not affected by surgical approach between endoscopic and open approaches (p =.76). CONCLUSION: Sinonasal adenocarcinomas are commonly identified in the sinonasal cavity and are associated with a relatively favorable prognosis, despite a substantial local failure rate of 30%. Advanced-stage tumors, sphenoid sinus and skull base invasion, and high-grade histology portend poor prognosis. In our experience, endoscopic resection was not associated with adverse outcomes and suggests that this minimally invasive approach can provide acceptable oncologic outcomes in selected patients. © 2013 Wiley Periodicals, Inc. Head Neck, 2014. Copyright © 2013 Wiley Periodicals, Inc. KEYWORDS: adenocarcinoma, endoscopy, sinonasal, skull base, surgery