1. © SPEX SamplePrep, Inc. 2011

2. The Basics Designed originally for Pioneer Hybrid International, a leading company in genetic crop science and now a division of DuPont The Geno/Grinder® provides efficient cell disruption of plant and animal tissues for the isolation of nucleic acids (RNA/DNA), enzymes, yeast and proteins.

3. © SPEX SamplePrep, Inc. 2011 Features & Benefits – Clamp Design Unique, true vertical action ensures complete sample processing Standard Clamp accepts two 96- well titer plates & various vials from 0.6mL to 50mL Large Clamp doubles throughput from 2 titer plates up to 4 and holds up to sixteen 50mL vials Full range of cryogenic accessories for temperature sensitive samples Patented

4. © SPEX SamplePrep, Inc. 2011 Who Can Benefit from a Geno/Grinder®? Institutions using high-throughput DNA sample processing Biotech / Pharmaceutical Agriculture/Crop Sciences Public Health Labs Colleges/Universities

5. © SPEX SamplePrep, Inc. 2011 Samples & Applications Rapid preparation of multiple samples for PCR sampling Fast disruption to allow extraction of Nucleic acids, RNA/DNA Lysing of yeast, bacterial cells Pesticide Analysis QuEChERS Method

6. © SPEX SamplePrep, Inc. 2011 QuEChERS Method Plant tissue from fruits and vegetables are homogenized using the Geno/Grinder® QuEChERS reagents are added for extraction, eliminating cross contamination Can be homogenized at room temperature or with Kryo-Tech® accessories Used by FDA Quick asy eap ffective ugged afe E Ch E R S

7. © SPEX SamplePrep, Inc. 2011 Geno/Grinder Accessories

8. © SPEX SamplePrep, Inc. 2011 Geno/Grinder® Accessories Titer Plates & Cap Mats Vials & Vial Sets Kryo-Tech® Racks & Holders Grinding Media

9. © SPEX SamplePrep, Inc. 2011 Titer Plates & Vials Titer Plates – 24-Well Square – 48-Well Rectangle – 96-Well Square – 96-Well Round Vials – Available sizes: 2mL, 5mL, 15mL, 50mL – NEW! 2mL pre-filled vials Zirconium, Silica Beads Stainless Steel balls Available in packs of 50 or 100 – NEW! Cryogenic Grinding Vial (P/N: 2255) Stainless steel vial set specifically designed for cryogenic grinding in the Geno/Grinder®

10. © SPEX SamplePrep, Inc. 2011 Geno/Grinder® Accessories Titer Plates & Cap Mats Vials & Vial Sets Kryo-Tech® Racks & Holders Grinding Media

11. © SPEX SamplePrep, Inc. 2011 Racks, Holders & Grinding Media Racks & Holders – Available for 2mL, 5mL, 15mL & 50mL – Durable, Sturdy Polyethylene material Grinding Media – Stainless Steel Grinding balls w/ dispenser – Silica & Zirconium grinding beads – Ceramic Grinding Media Pesticide Extraction

12. © SPEX SamplePrep, Inc. 2011 Geno/Grinder® Accessories Titer Plates & Cap Mats Vials & Vial Sets Kryo-Tech® Racks & Holders Grinding Media

13. © SPEX SamplePrep, Inc. 2011 Kryo-Tech® Accessories 2600 Cryo-Station – Holding station for samples which must be kept chilled to preserve RNA for extraction Cryo-Blocks & Holders – Maintains tissue samples at sub-zero temperatures during homogenization process – 2650 Cryo-Plate for Titer Plates – Available for all SPEX SamplePrep vial sizes

14. © SPEX SamplePrep, Inc. 2011 Application Notes & Resources

15. © SPEX SamplePrep, Inc. 2011 Application Notes Extensive library of Geno/Grinder® applications Examples SP025 – Quick DNA Extraction from Rice Seed (Wet) SP025 SP024 – Analysis of Pesticides in Fruit and Vegetable Products using a Standard QuEChERS Method and a Modified Method Involving the Geno/Grinder® SP024 SP018 – High-Throughput Disruption of Yeast in a 96-Well Format SP018 Also Available:

16. © SPEX SamplePrep, Inc. 2011 Product Demonstration Videos