1. Modernize Surgical Pathology - 2011 Genetics (Molecular) FunctionsMorphology (Physiologic or Normal)

2. Modernize Surgical Pathology - 2011  Physical injuries  Infections  Immune reactions  Mutation  Epigenetic errors Genetics (Molecular) FunctionsMorphology (Pathologic or Morbid)

3. Modernize Surgical Pathology - 2011  Physical injuries  Infections  Immune reactions  Mutation  Epigenetic errors Genetics (Molecular) FunctionsMorphology (Pathologic or Morbid)

4. Modernize Surgical Pathology - 2011  Physical injuries  Infections  Immune reactions  Mutation  Epigenetic errors Genetics (Molecular) FunctionsMorphology (Pathologic or Morbid) Environment

5.  Invisible causes  Molecules (gene products)  Functional proteins (Ab, enzymes, receptors, mediators, etc.)  Abnormal genes  Visible causes  Gross  Microscopic (light microscopy)  Submicroscopic (EM) Modernize Surgical Pathology - 2011

6.  Invisible causes  Molecules (gene products)  Functional proteins (Ab, enzymes, receptors, mediators, etc.)  Abnormal genes  Visible causes  Gross  Microscopic (light microscopy)  Submicroscopic (EM) Modernize Surgical Pathology - 2011

7.  Invisible causes  Molecules (gene products)  Functional proteins (Ab, enzymes, receptors, mediators, etc.)  Abnormal genes  Visible causes  Gross  Microscopic (light microscopy)  Submicroscopic (EM) Modernize Surgical Pathology - 2011

8.  Invisible causes  Molecules (gene products)  Functional proteins (Ab, enzymes, receptors, mediators, etc.)  Abnormal genes  Visible causes  Gross  Microscopic (light microscopy)  Submicroscopic (EM) Modernize Surgical Pathology - 2011

12.  1000GenomeProject: 629 people -> 7.3 TB  Cost of DNA sequencing drops 50% every 5 month  Next generation sequencing-> 40Gb/day (x4,000 !!) Modernize Surgical Pathology - 2011

14. Data tsunami Modernize Surgical Pathology - 2011

15.  50 slides / day  50 GB / day  1.5 TB / month  18 TB / year Virtual Slides Scan at x40 ~ 1GB / slide Modernize Surgical Pathology - 2011