1. DNA Rep & Protein Syn

2. 1928 – Griffith Transformation Experiment

3. 1941-Avery, McCarty, MacLeod

4. 1952-Hershey & Chase

5. 1952-Rosalind Franklin

6. 1953-Watson & Crick

7. Chromosomes, DNA, and Genes

8. DNA Structure Deoxyribonucleic Acid Double Helix Made of nucleotides Pentose Sugar (deoxyribose) Phosphate Nitrogenous Base A-T / C-G

9. Nucleotide

10. Nitrogenous Bases

11. Base Pairing

12. DNA is AntiParallel

13. DNA is still AntiParallel

14. How?

15. Possible Models for DNA Replication

16. Step 1

17. Step 2

19. DNA Replication Animation http://highered.mcgraw- hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535 ::535::/sites/dl/free/0072437316/120076/micr o04.swf::DNA%20Replication%20Fork http://highered.mcgraw- hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535 ::535::/sites/dl/free/0072437316/120076/micr o04.swf::DNA%20Replication%20Fork

20. Think About It If your DNA has 6 billion base pairs and generally there is one mistake made for every 100,000bp that are copied during replication, how many errors should result each time you copied your DNA? How many errors result in reality? Why?

23. Protein Synthesis Overview

25. RNA Structure Ribonucleic Acid Single Strand of nucleotides Pentose Sugar (ribose) Phosphate Nitrogenous Base A-U / C-G

26. RNA Nucleotide

28. 3 Types of RNA mRNA, tRNA, rRNA

29. Protein Synthesis Step 1 – Transcription Step 2 – Translation

30. Transcription Definition RNA Polymerase DNA Terminator 5’ Cap Poly – A Tail

31. Transcription Animation http://highered.mcgraw- hill.com/sites/0072507470/student_view0/cha pter3/animation__mrna_synthesis__transcripti on___quiz_2_.html http://highered.mcgraw- hill.com/sites/0072507470/student_view0/cha pter3/animation__mrna_synthesis__transcripti on___quiz_2_.html

32. mRNA Processing http://highered.mcgraw- hill.com/sites/9834092339/student_view0/chapter 16/animation_-_exon_shuffling.html

33. Translation Definition

34. mRNA Codons thedogbitthecatforfun the dog bit the cat for fun aug uuu cgc ggg cua aga uaa

35. tRNA

36. Ribosome

37. Codons

41. Codons

42. Translation Animation http://highered.mcgraw- hill.com/sites/0072943696/student_view0/chapter3/animat ion__how_translation_works.html http://highered.mcgraw- hill.com/sites/0072943696/student_view0/chapter3/animat ion__how_translation_works.html

44. Protein Folding

45. Protein Processing http://highered.mcgraw- hill.com/sites/0072943696/student_view0/chapter2/animat ion__protein_denaturation.html http://highered.mcgraw- hill.com/sites/0072943696/student_view0/chapter2/animat ion__protein_denaturation.html

46. Gene Regulation Repressible Operon – trp Operon Inducible Operon – lac Operon

47. trp Operon

48. lac Operon

49. cAMP & lac Operon

50. lac Operon Animation http://highered.mcgraw- hill.com/sites/007337797x/student_view0/chapter13/anim ation_quiz_- _combination_of_switches__the_lac_operon.html http://highered.mcgraw- hill.com/sites/007337797x/student_view0/chapter13/anim ation_quiz_- _combination_of_switches__the_lac_operon.html