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Unusual co-crystal of isonicotinamide: the structural landscape in crystal engineering by Srinu Tothadi, and Gautam R. Desiraju Philosophical Transactions.

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Presentation on theme: "Unusual co-crystal of isonicotinamide: the structural landscape in crystal engineering by Srinu Tothadi, and Gautam R. Desiraju Philosophical Transactions."— Presentation transcript:

1 Unusual co-crystal of isonicotinamide: the structural landscape in crystal engineering by Srinu Tothadi, and Gautam R. Desiraju Philosophical Transactions A Volume 370(1969):2900-2915 June 28, 2012 ©2012 by The Royal Society

2 Structure of the 1:1 salt of isonicotinamide (IN) and 3,5-dinitrobenzoic acid (DNBA). Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society

3 Unusual structure of the 2:1 IN–3,5-DNBA co-crystal. Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society

4 Some patterns seen in IN polymorphs. Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society

5 Supramolecular species that may exist in solution prior to crystallization of IN–DNBA salts and co-crystals. Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society

6 Solvent interruption of crystallization. Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society

7 Evolution of synthons in the polymorphs of phenylacetylene. Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society

8 Three different conformations of orcinol are hydrogen bonded in the orthorhombic polymorph. Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society

9 Derivatives of 6-amino-2-phenylsulphonylimino-1,2-dihydropyridine that were examined for polymorphism. Srinu Tothadi, and Gautam R. Desiraju Phil. Trans. R. Soc. A 2012;370:2900-2915 ©2012 by The Royal Society


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