1. Efficacy of a PEG/PG based Ocular Lubricant to Reduce Transient Visual Degradation Rolando Toyos, M.D. Whitney Hauser, O.D. The author of this poster has received research funding from Alcon Laboratories.

2. Rolando Toyos, M.D. Medical Director and Founder of Toyos Clinic, Memphis, Tennessee. President of The Sports Ophthalmology Society of America Team Ophthalmologist for the Memphis Grizzlies

3. Whitney Hauser, O.D. Clinical Director, Toyos Clinic, Memphis, Tennessee. Adjunct Faculty member, Southern College of Optometry. Center Director, TLC Laser Eye Centers, Memphis, Tennessee.

4. The Effect of the PEG/PG based Ocular Lubricant on Forced Stare The forced stare mimics activities such as: ▫Driving a car ▫Flying a plane ▫Playing certain sports (i.e. baseball) The forced stare is used to measure visual degradation, a factor related to dynamic visual acuity.

5. The Effect of the PEG/PG based Ocular Lubricant on Forced Stare Prospective, open-label, single-arm, single center study 30 subjects enrolled Eligibility requirements ▫Bilateral BCVA = 20/20 ▫History of episodic Dry Eye ▫Minimum TBUT = 10 seconds at baseline

6. The Effect of the PEG/PG based Ocular Lubricant on Forced Stare Subjects stared at Landolt E (adjusted to 20/20) at a distance of 60 feet and 6 inches without blinking and reported when target was unclear Visual degradation measured: ▫Before drop instillation of PEG/PG based lubricant ▫5 minutes after instillation of PEG/PG based lubricant Endpoint = Change in subject-reported clear vision

7. The Effect of the PEG/PG based Ocular Lubricant on Forced Stare Mean Clear Vision (MCV) duration = 6.46 seconds (± 3.00 seconds) before instillation MCV duration = 8.32 seconds (±3.86 seconds) after bilateral instillation of lubricant

8. The Effect of the PEG/PG based Ocular Lubricant on Forced Stare Instillation of the PEG/PG based Ocular Lubricant significantly increased MCV duration Improvement was observed in 26 of 30 subjects (87%) Mean Increase = 2.22 seconds Maximal MCV = 7.6 seconds

9. The Effect of the PEG/PG based Ocular Lubricant on Forced Stare 4 subjects observed a decreased duration of MCV post-treatment Mean Decrease = 0.54 seconds No adverse events were reported for this study

10. Conclusion Bilateral acute administration of PEG/PG ocular lubricant reduced visual degradation in these patients, suggesting an improvement in tear film stablilization. These results warrant further study of PEG/PG ocular lubricant use to improve dynamic visual acuity which is important in sports such as baseball and other activities like flying and driving.