1. Department of Immunology
Medical Immunology
Department of Immunology
Yiwei Chu

2. Medical Immunology
One of the six-year undergraduate professional courses
Overview of the immune system, immune response and regulation, immune diseases
Basic immunological theory (theory course)
Immunochemical and cellular techniques (experimental course)

3. Textbook Textbook: Cellular and Molecular Immunology
(Fifth Edition), Abul K. Abbas,
Andrew H. Lichtman
Reference: Immunobiology (Sixth Edition),
Charles A Janeway
Credit: Comprehensive evaluation combining the
theory examination and the experimental report
2 reasons, 1)only one authorized for sale in china, under the special agreement with Peiking University Medical press. 2) An exceptionally lucid guide to the latest immunology concepts. Immunology is not an easy concept to digest at first, but luckily this book explains the difficult topics quite well.

4. Department of Immunology
Established in the autumn of 1987, one of the first University Departments in the world devoted specifically to the study of the immune system. (Yale, in 1988)
A strong team with rich experiences in teaching and research

5. Department of Immunology
Rui He
Xiaowu Hong
Qing Lu
Bo Gao
Wei Xu
Yiwei Chu
Haifeng Gao
Yunlu Lin

6. General Properties of Immune Responses
Chapter 1
General Properties of Immune Responses

7. Content 1. History of Immunology 2. Innate and Adaptive Immunity
3. Adaptive Immune Responses

8. History of Immunology
IMMUNITY ←← IMMUNIS (EXEMPT)
Derived from the Latin word
Protection from legal prosecution
Now, in medical terms, it denotes resistance
to reinfection/free of disease.

9. History of Immunology Plague of Athens
Thucydides (430 BC)
Plague of Athens
“Yet it was with those who had recovered from the disease that the sick and the dying found most compassion. These knew what it was from experience, and had now no fear for themselves; for the same man was never attacked twice - never at least fatally”
Resistance to re-infection-Immunity
Fifth century

10. Define of Immunology
IMMUNITY
---protection from disease (infectious disease)
IMMUNE SYSTEM
--- organ, cell, molecule and gene
IMMUNE RESPNSE
--- response to the foreign substances

11. Define of Immunology
IMMUNE FUNCTIONS
---immune defence (infectious disease)
--- immune surveillance
--- immune homeostasis

12. Define of Immunity
Immunity refers to mechanisms used by the body as protection against environmental agents that are foreign to the body
Microorganisms
Foods
Chemicals, Drugs, Pollen etc.

13. History of Immunology Smallpox
Smallpox is a disease caused by the Variola major virus. Smallpox spreads very easily from person to person. Symptoms are flu-like and include high fever, fatigue and headache and backache, followed by a rash with flat red sores.

14. History of Immunology
Inhale powders made by skin lesions
Smallpox inoculation or variolation is a great invention of medicine in ancient China.

15. History of Immunology Edward Jenner memorial hall

16. Preparation of smallpox
History of Immunology
Preparation of smallpox

17. History of Immunology Edward Jenner Chinese-Variolation
Prophylactic measure against Smallpox
1798-Cow Pox/Vaccinia Induced Protection Against Small Pox-Vaccination
2 Centuries to Eradicate Small Pox
Greatest Triumph in Modern Medicine

18. History of Immunology
The announcement by the WHO in 1980 that smallpox was the first disease that had been eradicated worldwide by a program of vaccination

19. History of Immunology

20. History of Immunology Louis Pasteur (1822-1895) 1880 Vaccine
Vaccine to Anthrax
Vaccine to Rabies

21. Discovery of Humoral Immunity
History of Immunology
Discovery of Humoral Immunity
1890 von Behring and Kitasato:
Filtrates from cultures of Clost. tetani can confer protection.
Serotherapy
Serum of vaccinated people had substances that specifically bound to the relevant pathogen (ANTIBODIES)
Emil Adolf von Behring,
A German bacteriologist

22. History of Immunology
430 B.C. Thucydides People have been sicked free from illness
Song dynasty A divine doctor Emei Mountain Variolation
Jenner Vaccination
Pasteur Attenuated chicken cholera vaccine
1890 Behring/Kitasato Antitoxin ―Humoralimmunity hypothesis
1883 Metchnikoff Endocytosis - Cytoimmunity hypothesis
1905 Pirquet/Schick Horse serum sickness (Hypersensitivity)
1945 Owen/Burnet Immune tolerance hypothesis
1959 Burnet Clonal selection hypothesis

23. History of Immunology

24. WHAT is the immune system?
Complex defense system
Physiological function is to
Prevent infections
Eradicate established infections
Self/Nonself discrimination

25. Who has an immune system?
ALL animals.
Vert-Invert systems: analogous
Various vert systems: homologous

26. Who has an immune system?

27. Severe Fungal
Infection in a
Fruit Fly.

28. use preformed components to non-specifically clear the agent
How Does Immune System Work?
foreign agent
use preformed components to non-specifically clear the agent
produce specific components directed against the agent

29. Content 1. History of Immunology 2. Innate and Adaptive Immunity
3. Adaptive Immune Responses

30. Innate and Adaptive Immunity

31. Innate and Adaptive Immunity
Innate Immunity
Physical and chemical barriers
Phagocytic cells and NK cells
Blood proteins
Cytokines

32. Innate and Adaptive Immunity
Lymphocytes and their products
Antigen

33. Innate and Adaptive Immunity

34. Adaptive Immune Responses
Cardinal Features
Types
Cellular Components
Phases

35. Adaptive Immune Responses
Types
Humoral immunity
Cell-mediated immunity

36. Types of
Adaptive
Immunity

37. How can immunity be induced in an individual?
Yes
(T cells)

38. Adaptive Immune Responses
Cellular Components
Cardinal Features
Phases
Types

39. Adaptive Immune Responses

40. Adaptive Immune Responses
Phases
Cellular Components
Cardinal Features
Types

41. Adaptive Immune Responses
Cellular Components
Lymphocytes
- B, Th, CTL, NKT
Antigen-presenting cells(APCs)
- DC, Mj, B
Effector cells - Activated T cells, mononuclear phagocytes

42. Adaptive Immune Responses

43. Adaptive Immune Responses
Types
Phases
Cardinal Features
Cellular Components

44. Adaptive Immune Responses
Phases
Recognition of antigen
Activation of lymphocytes
Effector phase of immune responses:
Elimination of antigen
Homeostasis: Decline of immune responses

45. Adaptive Immune Responses

46. Adaptive Immune Responses
Recognition of antigen
Activation of lymphocytes
Effector phase of immune responses:
Elimination of antigen
Homeostasis: Decline of immune responses

47. Adaptive Immune Responses

48. Adaptive Immune Responses
Recognition of antigen
Activation of lymphocytes
Effector phase of immune responses:
Elimination of antigen
Homeostasis: Decline of immune responses

49. Adaptive Immune Responses
Antigen
Microbial products or
components of innate
immune responses to
microbes

50. Adaptive Immune Responses
Recognition of antigen
Activation of lymphocytes
Effector phase of immune responses:
Elimination of antigen
Homeostasis: Decline of immune responses

51. Elimination of antigen by antibody
Adaptive Immune Responses
Elimination of antigen by antibody

52. Elimination of antigen by T cells
Adaptive Immune Responses
Elimination of antigen by T cells

53. Adaptive Immune Responses
Recognition of antigen
Activation of lymphocytes
Effector phase of immune responses:
Elimination of antigen
Homeostasis: Decline of immune responses

54. Adaptive Immune Responses
At the end of an immune respose, the immune system returns to its basal resting state,in large part because most of the progeny of antigen-stimulation lymphocytes die by apoptosis.

55. Behring Koch Metchnikoff Ehrlich Richet Bordet
Landsteiner Theiler Bovet Burnet Medawar Porter Edelman Snell
Dausset Benacerraf Jerne Tonegawa Thomas Murray Doherty Zinkernagel

56. Department of Immunology
Thank you!