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Published byAustin Nichols Modified over 9 years ago
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The Microcirculation & Lymphatic System
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Structure of the Microcirculation Capillary System Metarterioles Precapillary sphincter Large “preferential channels” Small “true capillaries”
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Structure of the Microcirculation Venule Arteriole Preferential Channel Metarteriole Precapillary Sphincter True Arterioles
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Structure of the Microcirculation Basement Membrane (Collagen Type I) Vesicular Channel? Endothelial Cell Intercellular Cleft Plasmalemmal Vesicles (1 Endothelial Cell Thick)
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Transport Mechanisms Diffusion Intercellular Clefts Plasmalemmal Vesicles “Tight Junctions” (brain) Open Junctions (liver) Fenestra (kidney)
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Capillary Vasomotion Intermittent flow regulated by precapillary sphincters. Controlled by O 2 concentration.
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Diffusion through Capillary Membrane Lipid soluable – through endothelial cell membrane. Water soluable – through intercellular pores Size Dependent
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Diffusion through Capillary Membrane This figure illustrates that the permeability of substances through capillary membrane decreases roughly with the logarithm of size.
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