1. UNIVERSITY OF MISSOURI BIODESIGN AND INNOVATION FELLOWSHIP Program Sponsors:Program Coordinator Department of Surgery Department of Surgery Megan Jahnsen Co-director: Paul Dale, MD Administrative Assistant College of Engineering College of Engineering Whitney Hays Co-director: Gregg Scheller E-mail Missouri Technology Corporation www.MUBIODESIGN.com Mission: Improve health care through invention and implementation of new medical technologies through: 1.Fellowship Education 2.Faculty Collaboration

2. MU Biodesign and Innovation Fellowship First group of fellows 2007 3 Person Fellowship Team Selection Process – Physician-Surgical Resident, Medical Resident – Engineer-M.S. or higher – Business Professional-MBA ProductProduct Business Plan www.mubiodesign.com Top Needs & Solutions

3. Unique Features of MUBIP Proximity Promotes Collaboration:  Schools of Medicine, Engineering, Business, Law and Veterinary Medicine and large tertiary hospital all on 1 campus “Super” Fellow  Second Year of Fellowship Focused on Commercialization and Product Development Second Tier Gains  Faculty to Faculty Grad student Undergrad student Innovation Opportunities in Multiple Fields of Medicine  General Surgery  Vascular Surgery  Orthopedic Surgery  Neuro Surgery  Urology www.mubiodesign.com  Rehabilitation  Emergency Medicine  ICU  Dermatology  OB/GYN

4. Challenges Culture Change  Collaboration is Contagious “Valley of Death” for Innovations  Pre-Commercialization Funding Sustainable Funding for Program  Become self sustaining from commercialization/grants Transfer of Technology from Public University  University “owns” IP www.mubiodesign.com

5. Outputs of MUBIP Fellowship 2009 Outputs of MUBIP Fellowship 2009 200 “needs” during their clinical phase Sixteen invention disclosures were submitted to Tech Transfer Two provisional patents have been submitted License Device To Industry: Port-less Suction Device for Laparoscopic surgery Functional Prototype Tested in Animal Model Feasibility Study Discussions with Manufacturer and Distributor Licensing Options Being Explored by Second Year Fellow www.mubiodesign.com Create A Start Up: Dermele Skin Care, LLC Nanotechnology Based Injectable Dermal Filler and Beauty Cream Collaboration with Biological Engineers at University of Missouri Obtained Option to License Technology from the University Prototype with Preliminary Data Created Business Plan SBIR Phase I Application