1. Academic Centers Research Node of PECARN (“ACORN”) Supported by Project #U03 MC00001 from the Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services Supported by Project #U03 MC00001 from the Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services

2. Who We Are University of California, Davis Medical Center, University of California, Davis School of Medicine Children’s Hospital of Wisconsin, Medical College of Wisconsin Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine St. Louis Children’s Hospital, Washington University School of Medicine Primary Children’s Medical Center, University of Utah School of Medicine Children’s Hospital Medical Center, University of Cincinnati School of Medicine

3. University of California, Davis Medical Center University of California, Davis Nathan Kuppermann, MD, MPH Nathan Kuppermann, MD, MPH Chair, Department of Emergency Medicine, Chair, Department of Emergency Medicine, Professor of Emergency Medicine/Pediatrics Professor of Emergency Medicine/Pediatrics Emily Kim, MPH Emily Kim, MPH ACORN Node Administrator ACORN Node Administrator James Holmes Jr., MD, MPH James Holmes Jr., MD, MPH Professor of Emergency Medicine Professor of Emergency Medicine Leah Tzimenatos, MD Assistant Clinical Professor Department of Emergency Medicine/Pediatrics

4. Children’s Hospital of Wisconsin, Medical College of Wisconsin Marc Gorelick, MD, MSCE Medical Director, Emergency Department, Professor of Pediatrics and Emergency Medicine

5. Children’s Hospital of Philadelphia, University of Pennsylvania Elizabeth Alpern, MD, MSCE Assistant Professor of Pediatrics Kathy Shaw, MD, MSCE Division Chief, Pediatric Emergency Medicine, Professor of Pediatrics Evaline Alessandrini, MD, MSCE Associate Professor of Pediatrics

6. St. Louis Children’s Hospital, Washington University in St. Louis School of Medicine David Jaffe, MD Medical Director of Emergency Services, Professor of Pediatrics

7. American Family Children’s Hospital, University of Wisconsin School of Medicine & Public Health Walton Schalick, MD, PhD Ethics Consultant Assistant Professor of Bioethics, Medical History, Pediatrics, Orthopedics & Rehabilitation, History of Science, and History University of Wisconsin-Madison

8. Primary Children’s Medical Center, University of Utah Douglas Nelson, MD Douglas Nelson, MD Professor of Pediatrics Professor of Pediatrics Associate Chief, Pediatric Emergency Medicine Associate Chief, Pediatric Emergency Medicine

9. Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine Richard Ruddy, MD Director, Division of Emergency Medicine Professor of Clinical Pediatrics

10. Where We Are Located

11. ACORN Organizational Structure

12. ACORN Proposal Generation & Review Process

13. ACORN Strengths ACORN investigators have high-level training and expertise in epidemiology/biostatistics/ethics ACORN members are senior-level PEM investigators with substantial research, grant writing and publication experience, and leadership in the field of PEM ACORN research proposals are subject to a rigorous internal review process with participation by all core ACORN investigators

14. ACORN-lead Research Ongoing Projects: Randomized Trial of Oral Dexamethasone in Acute Bronchiolitis (subanalyses ongoing)Randomized Trial of Oral Dexamethasone in Acute Bronchiolitis (subanalyses ongoing) PECARN Core Data ProjectPECARN Core Data Project Head Injury ProjectHead Injury Project Cervical Spine Injury ProjectCervical Spine Injury Project Intra-abdominal Injury ProjectIntra-abdominal Injury Project Patient Safety ProjectPatient Safety Project Quality Measures ProjectQuality Measures Project

15. ACORN-lead Research Future Research Endeavors: Randomized Trial of IV Magnesium for Treatment of Pain Crises in Sickle Cell DiseaseRandomized Trial of IV Magnesium for Treatment of Pain Crises in Sickle Cell Disease Randomized Trial of C-Spine Immobilization in Children at Low-Risk for C-Spine InjuryRandomized Trial of C-Spine Immobilization in Children at Low-Risk for C-Spine Injury Safety of Emergency Department Procedural SedationSafety of Emergency Department Procedural Sedation Medical Error Reduction in Pediatric Emergency MedicineMedical Error Reduction in Pediatric Emergency Medicine RCT of Fluid Therapy for DKARCT of Fluid Therapy for DKA Knowledge Translation Research of Information Generated by Completed PECARN ResearchKnowledge Translation Research of Information Generated by Completed PECARN Research

16. Concluding Statement Concluding Statement The ACORN Node of PECARN is committed to applying our strengths and expertise to the study of the prevention and treatment of acutely ill and injured children. We will maintain strong collaborations with all other Nodes of PECARN, the MCHB/EMSC, and EMSC practitioners. We are confident that the strong commitment of all the Nodes of PECARN will insure the success of this robust and exciting network.