1. Tomris Cesuroglu, MD Institute for Public Health Genomics PAOG nascholing Jeugdgezondheidszorg Maastricht, 25 January 2011

2. http://childhealthresearch.eu Research into Child Health in Europe RICHE http://childhealthresearch.eu

3. RICHE An EU funded project (FP7, Mar 2010 to Feb 2013) A project for child health researchers, practitioners, policy makers, and those who make decisions affecting children Defining the current pattern of child health research in Europe, seeing what's not being done, and identifying paths to the future of the research Future proofing child health research policy in Europe Meeting the future needs of European policy makers, funders, and children.

4. http://childhealthresearch.eu Home Page

5. http://childhealthresearch.eu An example

6. http://childhealthresearch.eu What's to be done? Join us! Put up your own work Put up your colleagues Put up your projects Put up your report Put up your funders

7. Perspectives in Personalized Health Care Tomris Cesuroglu, MD Institute for Public Health Genomics PAOG nascholing Jeugdgezondheidszorg Maastricht, 25 January 2011

8. Life style External factors Genetic structure _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Genetic diseases External factors Complex diseases 1% of burden of disease 22% of burden of disease 77% of burden of disease Disease threshold *Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research

9. An Example to a Single Nucleotide Polymorphism (SNP) TAT TCG TAC GGC TAC ATA CGT ACC GTA AAT TCG ATT CGA TGA ATA AGC ATG CCG ATG TAT GCA TGG CAT TTA AGC TAA GCT ACT Stop Codon Start Codon ┐└

10. An Example to a Single Nucleotide Polymorphism (SNP) TAT TCG TAC GGC TAC ATA CGT GCC GTA AAT TCG ATT CGA TGA ATA AGC ATG CCG ATG TAT GCA CGG CAT TTA AGC TAA GCT ACT Stop Codon Start Codon ┐└

12. Genetic Polymorphism Dark skin Fair skin Which one is better? Gene and Environment/Life Style Interaction *Slide series used with the courtesy of GENAR Institute for Public Health and Genomics Research

13. Fair skinDark skin Norway Happily living in Fjords Nigeria Happily living under African sun Genetic variation: Is it good or bad?

14. Fair skinDark skin Norway Nigeria Genetic variation: Is it good or bad?

15. Fair skinDark skin Norway Nigeria Gets red Burns Melanoma develops Genetic variation: Is it good or bad?

16. Fair skinDark skin Norway Not enough sunshine Vitamin D deficiency Develops osteoporosis Nigeria Gets red Burns Melanoma develops Genetic variation: Is it good or bad?

17. Fair skinDark skin Norway Not enough sunshine Vitamin D deficiency Develops osteoporosis Nigeria Positive intervention: Protecion from the sun Genetic variation: Is it good or bad?

18. Fair skinDark skin Norway Positive intervention: Vitamin D supplements Nigeria Positive intervention: Protecion from the sun Genetic variation: Is it good or bad?

19. GSTP 1 Effective detoxification GSTP 1 (A313G Homozygous) Ineffective detoxification Transcription (mRNA production) Translation in ribosom (synthesis of amino acid chain ) Protein Transcription (mRNA production) Translation in ribosom (synthesis of amino acid chain ) Protein Eric Assamoa

20. Pathology Development Phase I Disease Phase III Check-Up Early Diagnosis Disease Threshold Early Symptoms Threshold Diagnosis and Treatment Genetic Predisposition Life Style and Environmental Conditions Conception Death Early Symp. Phase II *Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research

21. Thank you for your attention! Tomris Cesuroglu, MD t.cesuroglu@maastrichtuniversity.nl