1. ETPGAH UK Mirror Group Progress report Phil Sketchley - Chief Executive National Office of Animal Health Ltd

2. UK Mirror Group > Structure and functioning (stakeholders, chair, secretariat, meetings, etc.) > Action plan and selection of priorities > Communication at national level > Directing national funding > Work programme for 2008

3. Structure of UK Mirror Group > Secretariat: VMD (Veterinary Medicines Directorate) – Professor Steve Dean – Chief Executive – Dr Jack Kay – VMD-R&D and Science Policy Manager – Gemma Adams – secretary > Chair: Phil Sketchley - NOAH – National Office of Animal Health – representing UK animal medicines industry. > Current stakeholders: – Professor Quintin McKellar - Dean RVC- Royal Vet College – Professor Julie FitzPatrick - Chief Executive, Moredun Research Institute. – Dr John Preston MRCVS – VMD Board. – Catherine McLaughlin – Animal Health and Welfare, National Farmers Union, – Dr Alex Morrow – Defra Animal Health and Welfare and Eurogap. – Professor Jim Scudamore – Liverpool Vet School & ETPGAH consultant. – Invitation to CVO (vacant)

4. Progress of UK Mirror Group > 2 meetings held so far –hosted by Defra > July 2007 and Jan 2008 > Key Actions @ first meeting: ESTABLISHING GAPS in Research > To assist in developing a common priority list, it was agreed each member would submit details of their perceived priorities: – 7 most important exotic diseases – 7 most important endemic diseases – 7 most important zoonotic diseases – 7 most important products for treatment – 7 most important areas for further research

5. Exotic Diseases Priorities > Avian influenza > Foot and Mouth > Blue tongue disease > Newcastle disease > Veterinary Laboratories Agency; > Institute for Animal Health, Compton; Centre for Infections, > Health Protection Agency > Institute for Animal Health, Pirbright > Veterinary Laboratories Agency; > Scottish Agricultural College Disease UK groups with expertise

6. Endemic Diseases Priorities > Mastitis (multi-agent) > Tuberculosis (and diagnostic tuberculins) > Parasitic gastroenteritis > Lameness > University of Bristol; > Veterinary Laboratories Agency, Moredun, > AFBI Stormont, > Imperial College; > Institute for Animal Health, Compton > Moredun Research Institute > University of Bristol; > Royal Veterinary College; > University of Liverpool; > Scottish Agricultural College; > University of Bristol Disease UK groups with expertise

7. Zoonotic Disease Priorities > VTEC 0157 > Campylobacter > Salmonella > Antimicrobial resistance > Veterinary Laboratories Agency; > Health Protection Agency; > University of Edinburgh; > Imperial College > Veterinary Laboratories Agency, > Institute for Animal Health, Compton; > University of Bristol; > University of Cambridge; > University of Nottingham; University of Oxford > Veterinary Laboratories Agency, > Institute for Animal Health, Compton; > Institute of Food Research, Norwich; > University of Bristol; > University of Cambridge; > University of Nottingham > Veterinary Laboratories Agency; > University of Birmingham; > Health Protection Agency; > University of Bristol; > Royal Veterinary College Disease UK groups with expertise

8. Summary

9. Others? > West Nile Fever > Echinococcus multilocularis > Classical swine fever > African Horse Sickness > Leishmaniasis (via PETS) > Heartworm (dirofilaria immitis) > Fascioloiasis > Anthrax > Cryptosporidiosis > Toxoplasmosis > Leptospirosis > Toxoplasmosis > Sheep scab > African Swine Fever > Bovine viral diarrhoea > Porcine reproductive and respiratory syndrome > Tick-borne diseases > Necrotic enteritis > Infectious bronchitis > Gumboro & Mareks > Brachyspira > Neospora

10. > Cat Flu (emerging virulent strains and novel approaches to control) > Border’s disease > Strangles > Feline Immunodeficiency Virus > Mycoplasma > Feline Infectious Peritonitis > Myxomatosis > Angiostrongylus vasorum > E. Cuniculli > Pasterellosis (rabbits) > Rabies > Nosema ceranae infestation > Equine protozoal myeloencephalitis > Porcine Multisystemic Wasting disease (PMWS) pigs > Transmissable Spongiform Encephalopathies > Caseous Lymphadenitis (sheep) > Clostridium botulinum ANNEX: ADDITIONAL DISEASES AND ISSUES OF IMPORTANCE TO UK TO BE KEPT UNDER REVIEW

11. > Infectious pancreatic disease (IPN) salmon > Bovine abortion > Bovine respiratory disease > Swine respiratory disease > Poultry coccidiosis/ colisepticaemia > Varroa destructor infestation > Digitial Dermatitis > Neopspora vaccine > Anthelmintic resistance (sheep mainly) > Caseous Lymphadenitis (sheep) > RabiesOrf/ringworm > Listeriosis > Lyme Borreliosis > Blackhead (turkeys) > Bee products – Small Hive Beetle, etc. > Anticancer medicines for companion animals > Antibiotic to treat nosema (both apis and ceranae forms) > Fish infectious diseases and issues (e.g. ERM, PKD, sea lice) ANNEX: ADDITIONAL DISEASES AND ISSUES OF IMPORTANCE TO UK TO BE KEPT UNDER REVIEW

12. > Anthelmintics (new mode of action chemical family and vaccines) > Alternatives to animal challenge tests for vaccines > DIVA vaccines > Risk based methodology for re-testing veterinary vaccines > DNA vaccines > Coccidiosis > Chlamydiosis > Equine viruses > Brucellosis > Ruminant respiratory viruses > TSEs

13. Centres of expertise for collaboration with UK Mirror Group-summary > Institute for Animal Health (Pirbright) - FMD, Bluetongue > Institute for Animal Health (Compton) - Salmonella, Campylobacter, Mareks Disease, Coccidiosis > VLA (veterinary Laboratories Agency) - TB, Rabies, AI > Moredun - Parasitic gastroenteritis, Chlamydiosis, ParaTB > University of Bristol - Campylobacter, Salmonella > University of Cambridge - Salmonella, Campylobacter > RVC - influenza (epi), Lameness, Antimicrobial resistance. > AHT (Animal Health Trust) - equine viruses > Stormont - Brucellosis, ruminant respiratory viruses

14. Communication at national level > So far just within immediate group > Now we intend to embrace a larger audience of research establishments

15. Directing national funding > No specific actions initiated yet. > This will be addressed at our next meeting in April > Also to determine a detailed work programme after identifying collaboration with other national mirror groups

16. UK Mirror Group ETPGAH