1. insulin deficiency Too much sugar in blood vessels (hyperglycemia) vessel damage heart nerves retina blindness heart attack gangrene amputation kidneys can’t handle excess sugar kidney failure kidney transplant dialysis cells can’t absorb sugar ketones build up blood becomes acidic glycosuria polyuria polydipsia dehydration shock coma death Concept Map of Diabetes cells no longer sensitive to insulin No insulin (not enough) cells burn fat and protein only 1 Not enough sugar IN cells kidneys heart disease retinal damage Neuro- pathy numbness 2 3 4 5 6 1 2

2. insulin deficiency Too much sugar in blood vessels (hyperglycemia) vessel damage heart nerves retina blindness heart attack gangrene amputation kidneys can’t handle excess sugar kidney failure kidney transplant dialysis cells can’t absorb sugar ketones build up blood becomes acidic glycosuria polyuria polydipsia dehydration shock coma death Concept Map of Diabetes cells no longer sensitive to insulin No insulin (not enough) cells burn fat and protein only Not enough sugar IN cells kidneys heart disease retinal damage Neuro- pathy numbness 1 2

3. insulin deficiency Too much sugar in blood vessels (hyperglycemia) vessel damage heart nerves retina blindness heart attack gangrene amputation kidneys can’t handle excess sugar kidney failure kidney transplant dialysis cells can’t absorb sugar ketones build up blood becomes acidic glycosuria polyuria polydipsia dehydration shock coma death Concept Map of Diabetes cells no longer sensitive to insulin No insulin (not enough) cells burn fat and protein only Not enough sugar IN cells kidneys heart disease retinal damage Neuro- pathy numbness 1 2 1 2 3 4 5 6