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COMPOSITION OF LIPIDS Lipoproteins Apolipoproteins Lipoproteins Apolipoproteins Cholesterol Protein Triglyceride Phospholipid.

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Presentation on theme: "COMPOSITION OF LIPIDS Lipoproteins Apolipoproteins Lipoproteins Apolipoproteins Cholesterol Protein Triglyceride Phospholipid."— Presentation transcript:

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8 COMPOSITION OF LIPIDS Lipoproteins Apolipoproteins Lipoproteins Apolipoproteins Cholesterol Protein Triglyceride Phospholipid

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11 Chylomicron Very Low Density Lipoprotein Low Density Lipoprotein Intermediate Density Lipoprotein High Density Lipoprotein Chylomicron Very Low Density Lipoprotein Low Density Lipoprotein Intermediate Density Lipoprotein High Density Lipoprotein

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16 CHOLESTEROL METABOLISM Exogenous Endogenous Reverse Cholesterol Transport LDL Uptake Exogenous Endogenous Reverse Cholesterol Transport LDL Uptake

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24 HMG CoA Reductase Inhibitors

25 Fibric Acids ↓ TG synthesis ↓ lipoprotein synthesis ↓ excretion of lipoproteins from liver; primarily VLDL ↓ synthesis of cholesterol ↑ production of sterols ↑ HDL

26 Bile Acid Binding Resins Nicotinic Acid Bind bile salts in gut Cholesterol eliminated in the feces Liver uses other sources of cholesterol (LDL) to make more bile

27 Nicotinic Acid Inhibits liver secretion of VLDL Reduced serum LDL Inhibits removal of HDL Increases excretion of sterols in the feces

28 Fibric Acids ↓ LDL ↓ VLDL ↓ TG Bile Acid Binding Resins ↑ HDL ↓ LDL ↓ VLDL ↓ TG HMG CoA Reductase Inhibitors Nicotinic Acid

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30 Dufaux, International Journal of Sports Medicine, 1982 TRIGLYCERIDES & TRAINING Increase Decrease No Change Numbers of Studies

31 Dufaux, International Journal of Sports Medicine, 1982 CHOLESTEROL & TRAINING Increase Decrease No Change Numbers of Studies

32 Dufaux, International Journal of Sports Medicine, 1982 LDL & TRAINING Increase Decrease No Change Numbers of Studies

33 Dufaux, International Journal of Sports Medicine, 1982 HDL & TRAINING Increase Decrease or No Change Numbers of Studies

34 Tolfrey K, et al Sports Medicine 29:99-112, 2000 Pediatric Triglyceride response to Exercise Increase Decrease No Change

35 Increase Decrease No Change Numbers of Studies Pediatric Total Cholesterol response to Exercise Tolfrey K, et al Sports Medicine 29:99-112, 2000

36 Increase Decrease No Change Numbers of Studies Pediatric LDL response to Exercise Tolfrey K, et al Sports Medicine 29:99-112, 2000

37 Increase Decrease No Change Numbers of Studies Pediatric HDL response to Exercise Tolfrey K, et al Sports Medicine 29:99-112, 2000

38 Hurley, B.F., MSSE 21:689-693, 1989. RESISTANCE TRAINING

39 Hurley, B.F., MSSE 21:689-693, 1989.

40 CHOLESTEROL & TRAINING Whaley et al, J Cardiopulm Rehab 12:42-50, 1992 Pre Post Total Cholesterol

41 Lipid Research Clinics, JAMA 251:356-374, 1984. Reduction in Risk related to Reduction in Cholesterol

42 Risk reduction associated with a 20.7 mg/dL reduction in Total Cholesterol Lipid Research Clinics, JAMA 251:356-374, 1984.

43 Lehmann, R, et al. European J Clin Invest 31:37-44, 2001. HDL Subfractions and Physical Activity

44 Lehmann, R, et al. European J Clin Invest 31:37-44, 2001. HDL Subfractions and Physical Activity

45 Kraus, WE, et al. N Eng J Med 347:1483-1492, 2002 Exercise & Lipid Subfractions

46 Kraus, WE, et al. N Eng J Med 347:1483-1492, 2002 Exercise & Lipid Subfractions

47 Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993. HDL Subfractions and Physical Activity

48 Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993. HDL Subfractions and Physical Activity

49 Lp(a) and Physical Activity Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993.

50 Lopez, A, et al Atherosclerosis 20:1-9, 1974. How does HDL change with exercise?

51 Lopez, A, et al Atherosclerosis 20:1-9, 1974. How does HDL change with exercise?

52 Grandjean, et al J Applied Physiology 89:472-480, 2000

53 Hyper Normo Grandjean, et al J Applied Physiology 89:472-480, 2000

54 CETP and Physical Activity Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993.


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