1. Welcome to Immunology Course

2. Facebook: Antitelija Limfocitic
IMMUNOLOGY
Prof. dr Vera Pravica
Prof. dr Dušan Popadić
Doc. dr Miloš Marković
Assist. dr Emina Savić
Tel
Facebook: Antitelija Limfocitic

3. Advice
for successful learning
and passing the exam

4. Immunology independent subject (separated from Microbiology)
winter semester
45 hours during 15 week
Seminars (20)
Lectures (15)
Labs (10)

5. Seminars, Labs and Lectures are integral parts of the course
Student are allowed to be absent on seminar or lab twice
during the semester

6. Textbook
Basic Immunology: Functions and Disorders of the Immune System
Authors: Abbas AK, Lichtman AH.
Publisher: Elsevier
3rd edition updated, 2011
.ppt presentations and authorised supplementary material
(available on web site) 6

7. Continuous assessment
Activity during the course (seminars, labs and lectures)
through activity points
Presence on lectures noted separately
Colloquium – divided in three separate mini-tests after every 4 weeks (5th, 9th and 13th week)
Final test 7

8. Colloquium Test (multiple choice – 1 correct answer out of 4)
It consists of 30 questions in total
(divided into 3 mini tests with 10 questions each)
first: in the 5th week (first 4 chapters from the textbook)
second: in the 9th week (chapters 5 to 8)
third: in the 13th week (chapters 9 to 12 plus immunological methods and vaccines)
1 point for each correct answer (max 30 points)
15 minutes per mini test

9. Final test 70 points in total consists of:
20 multiple choice questions with one correct answer out of four
(2 points for each correct answer, max. 40 points)
5 fill-in questions where correct word should be filled in the blanks
(max. 20 points)
2 questions that require short answers up to five sentences
(max. 10 points)
Threshold for passing the final test is 36 points (50% plus 1)

10. Final mark in Immunology
For the passing of the Immunology exam the minimum of 51 points (out of 100) should be collected on condition that the 50% of points plus one (minimally 36) has been reached in the final test
Note: If the student collected less than 15 points in colloqium (i.e. 50%),
he/she must perform better than 36 in the final test
100 points in total
(six)
(seven)
(eight)
(nine)
(ten)
Activity points (max. 10 points) are added only if the minimum of 51 points has been reached

11. Introduction to immune system
Innate and adaptive immunity
Types of adaptive immunity
Properties and phases of adaptive immune response
Central and peripheral lymphoid organs
Lymphocyte recirculation

12. IMMUNITY
INNATE
(Natural)
(Native)
ADAPTIVE
(Aquired)

13. Principle mechanisms of innate and adaptive immunity

14. Principle mechanisms of innate and adaptive immunity

15. The most important cells of the immune system

16. Chain of events in infection

17. Pathogen(s) enter(s) tissue

18. Pathogen(s) enter(s) tissue

19. Pathogen(s) enter(s) tissue

20. Macrophages recognize (and eliminate) pathogens

21. Macrophages recognize (and eliminate) pathogens

22. Macrophages recognize (and eliminate) pathogens

23. Inflammation is induced and PMNs attracted

24. Inflammation is induced and PMNs attracted

25. Antigen-presenting cells (APCs) capture antigen(s)

26. Antigen-presenting cells (APCs) capture antigen(s)

27. APCs migrate to draining lymph node

28. APCs migrate to draining lymph node

29. APCs migrate to draining lymph node

30. APCs migrate to draining lymph node

31. APCs migrate to draining lymph node

32. APCs migrate to draining lymph node

33. APCs migrate to draining lymph node

34. APCs migrate to draining lymph node

35. APCs migrate to draining lymph node

36. T cells are activated by APCs

37. T cells are activated by APCs

38. T cells are activated by APCs

39. B cell are activated (helped by T cells)

40. B cell are activated (helped by T cells)

41. B cell are activated (helped by T cells)

42. Activated B cells (plasma cells) produce antibodies (Abs)

43. Activated B cells (plasma cells) produce antibodies (Abs)

44. Activated B cells (plasma cells) produce antibodies (Abs)

45. Activated B cells (plasma cells) produce antibodies (Abs)

46. Activated T cells and Abs leave lymph node...

47. ... enter blood stream and...

48. ... enter blood stream and...

49. ... migrate to site of infection

50. ... migrate to site of infection

51. ... migrate to site of infection

52. Activated T cells stimulate phagocytes

53. Activated T cells stimulate phagocytes

54. Activated T cells stimulate phagocytes

55. Activated T cells stimulate phagocytes

56. Abs neutralize pathogens and stimulate phagocytes

57. Abs neutralize pathogens and stimulate phagocytes

58. Abs neutralize pathogens and stimulate phagocytes

59. Abs neutralize pathogens and stimulate phagocytes

60. Abs neutralize pathogens and stimulate phagocytes

61. Pathogen is eliminated

62. Principle mechanisms of innate and adaptive immunity

63. Mechanisms of adaptive immunity
- acquired throughout a lifetime of an individual
- result of previous contact with pathogen
- present in vertebrates

64. Properties of adaptive immunity
- diversity and specificity
- memory
- clonal expansion
- specialization
- autotolerance
- stimulation of mechanisms of innate immunity

65. Types of adaptive immunity

66. Phases of adaptive immune response

67. Types of lymphocytes

68. Lymphoid organs

69. Lymph node structure

70. Lymph node structure

71. Recirculation of T lymphocytes

72. The morphology of the spleen

74. Introduction to immune system
Innate and adaptive immunity
Types of adaptive immunity
Properties and phases of adaptive immune response
Central and peripheral lymphoid organs
Lymphocyte recirculation

75. a. b. c. d. e. f. g. h. i. j. d. g. h. a. c. b. e. f. j. i.1.
Innate immunity is also called a.
phagocytes and NK cells 2.
Mechanisms of innate immunity mediate b.
humoral and cellular immunity 3.
First line of defence of innate immunity is provided by c.
B and T lymphocytes 4.
Cells of innate immunity are d.
natural or native immunity 5.
Cells of adaptive immunity are e.
diversity, specificity and memory 6.
Types of adaptive immunity are f.
bone marrow and thymus 7.
Important properties of adaptive immune cells are g.
early defence against infectious agents 8.
Human central (primary) lymphoid organs are h.
epithelial barriers 9.
Human peripheral (secondary) lymphoid organs are i.
peripheral lymphoid organs
10.
Primary adaptive immune response begins in j.
lymph nodes, spleen and MALT
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10.____ d. g. h. a. c. b. e. f. j. i.