1. QOD How are the lymphatic system and the cardiovascular system linked? What are the functions of the lymphatic system?

2. Chapter 14 Lymphatic System and Immunity

3. Intro  Functions:  Structures –Lymphatic vessels –Organs –Nodes –Lacteals –Lymph

4. Fig. 14.01

6. 14.2 Lymphatic Pathways  Lymphatic capillaries  Lymphatic vessels  Lymph nodes  Lymphatic trunks  Collecting ducts –Thoracic duct –Right lymphatic duct  Subclavian vein

7. Fig. 14.04

8. Fig. 14.05

9. 14.3 Lymph  Formation –Filtration  interstitial fluid  Function –Nutrients –Immunity

10. Schematic representation of lymphatic vessels Slide number: 1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

11. Schematic representation of lymphatic vessels Slide number: 2 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Lymphatic capillaries Pulmonary capillary network Systemic capillary network Lymphatic capillaries Lymph node Lymphatic vessels

12. Schematic representation of lymphatic vessels Slide number: 3 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Lymph node Lymphatic vessels Lymphatic capillaries Pulmonary capillary network Systemic capillary network Lymphatic capillaries

13. 14.4: Lymph movement  Hydrostatic pressure  Muscular activity –Skeletal muscle –Smooth muscle  Breathing –Inhalation and pressure change  Edema

14. QOD What do tonsillitis, swollen glands and elephantitis all have in common?

15. 14.5 Lymph Nodes  Structure –Contains: –Hilum –Lymph nodules –Lymph sinuses –Tonsils and Peyer’s patches  Functions –Filtering –Surveilance

17. Fig. 14.07

18. Fig. 14.08

19. 14.6: Thymus and Spleen  Thymus –Structure and location –Lymphocytes: T cells –Thymosins  Spleen –Structure: Lobules  In venous sinuses, blood  White pulp and red pulp –Function

20. Fig. 14.09a

21. Fig. 14.10a

22. QOD List the 6 types of innate defenses and provide specific examples of each.

23. 14.7 Body Defenses  Pathogen and Infection  Innate defense –Nonspecific  Adaptive defense –Lymphocytes –Antigens

24. Innate Defenses  Species Resistance  Mechanical Barriers  Chemical Barriers –Interferons  Fever  Inflammation  Phagocytosis

25. QOD Compare and contrast innate defenses to adaptive defenses.

26. Adaptive Defenses  Antigens  Lymphocyte origins –T Cells –B Cells

28. QOD List and describe the functions of the different types of B cells and T cells.

29. Lymphocyte Functions  T Cells –Cellular immune response  Cytokines, interleukins and CSF  B Cells –Plasma cells – humoral immune response  Antibodies/immunoglobulins –Memory cells

30. T Cells and Cellular Immune Response  Activation of T cells –Antigen presenting cells  Macrophages –Macrophage breaks down bacterium –MHC binds to fragments and penetrates membrane –Helper t cell contacts and is activated –Helper t cell stimulates B cells to produce antibodies

31. Fig. 14.13

32. Cytotoxic T Cells  Recognizes MHC on virus-infected cell or cancerous cell  Activates upon contact with MHC- antigen complex  Proliferate  Produce proteins that cuts membrane of infected cells

33. B Cell and Humoral Response  Activation – 2 ways  Proliferation  Clones  Differentiation  plasma cells and memory cells  Plasma cells –Antibodies  Memory cells

35. Antibody Actions: The Complement System

36. QOD What is an autoimmune disease? Identify one and describe it.

37. Responses and Classification  Responses –Primary Response –Secondary Response  Classification –Passive immunity –Active immunity  Naturally acquired  Artificially acquired

38. Fig. 14.16

39. Allergies and Autoimmune Disease  Allergies –Allergen –Delayed-reaction – T cells and macrophages  Repeated exposure –immediate-reaction – B Cells, IgE, Mast cells and histamine  Autoimmune response

40. Diseases/Disorders of the Lymphatic system and Immunity  Tissue/Organ rejection –Graft-versus-host disease  Lymphomas  Tonsillitis and appendicitis  HIV/AIDS  Lupus  Rheumatoid arthritis  Diabetes mellitus type 1