1. PATHOGENOMIC RESEARCH IN HUNGARY PRESENT STAGE AND PERSPECTIVES Ideas for cooperation L. Emődy - B. Nagy ERE-NET PathoGenoMics Meeting Bonn, 07.-08. April, 2005

2. CENTERS OF PATHOGENOMIC RESEARCH IN HUNGARY

3. IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS Enterobacterial pathogenomics: Human intestinal and extraintestinal E. coli, Salmonella, Yersinia Univ. Med. Sch. Pécs, Dept. Med.Microbiol. Immunol. Contact person: Levente Emődy, levente_emody@yahoo.co.uklevente_emody@yahoo.co.uk Veterinary aspects of E. coli and Salmonella Vet. Med. Res. Inst., Hungarian Acad. Sci. Contact person: Béla Nagy, bnagy@vmri.hubnagy@vmri.hu Genome plasticity of Escherichia coli: genome evolution studies Biol. Res. Ctr. Szeged Contact person: György Pósfai, posfaigy@nucleus.szbk.u-szeged.huposfaigy@nucleus.szbk.u-szeged.hu

4. IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS (ctnd) Gram positive pathogens: pathogenomics and resistance mechanisms Staphylococcus, Streptococcus (including pneumococci), Enterococcus Contact person: Ferenc Rozgonyi, rozfer@net.sote.hurozfer@net.sote.hu Anaerobes: pathogenomics and resistance mechanisms Bacteroides spp. Clostridium difficile Univ. Med. Sch., Szeged, Dept. Clin. Microbiol. Contact person: Elisabeth Nagy, nagye@mlab.sote.u-szeged.hunagye@mlab.sote.u-szeged.hu

5. IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS (ctnd) Helicobacter pylori: interactions governed by genetic makeup of the host and parasite Univ. Med. Sch. Szeged, Dept. Med. Microbiol. Immunobiol. Contact person: Yvette Mándi, yvette@comser.szote.u-szeged.huyvette@comser.szote.u-szeged.hu Mycobacteria: molecular mechanisms of reactivation Univ. Med. Sch. Szeged, Dept. Med. Microbiol. Immunobiol. Contact person: András Miczák, miczak@comser.szote.u-szeged.humiczak@comser.szote.u-szeged.hu Chlamydia pneumoniae: genetic factors involved in the development of atherosclerosis National Center for Epidemiology Contact person: Éva Gönczöl, gonczole@oek.antsz.hu

6. IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS (ctnd) Fungal pathogens: genetic background of virulence, and development of new antifungal agents Univ. Szeged, Fac. Sci. Dept.Microbiol. Contact person: Csaba Vágvölgyi, csaba@bio.u-szeged.hucsaba@bio.u-szeged.hu Univ. Debrecen, Fac. Sci. Dept. Microbiol. Contact person: Pócsi István, pocsi@tigris.unideb.hupocsi@tigris.unideb.hu Univ. Med. Sch. Debrecen, Dept. Med. Chem Contact person: Viktor Dombrádi, dombradi@jaguar.unideb.hudombradi@jaguar.unideb.hu Univ. Pécs, Fac. Sci. Dept. Gen. Envirol. Mirobiol. Contact person: Miklós Pesti, micro@ttk.pte.humicro@ttk.pte.hu

7. Hungarian Scientific Research Fund (OTKA) grants involving pathogenomic topics: Attenuation of Escherichia coli by global regulatory mutations. (Emődy L.) Investigations on the pathogenicity of enteroinvasive bacteria. (Pál T.) Investigations with a regulatory mutant vaccine candidate Salmonella enterica strain eliciting cross-immunity in mice. (Nagy G.) The role of horizontal gene transfer in the evolution of enterotoxic and cytotoxic Escherichia coli bacteria. (Nagy B.) Occurence in Hungary, and molecular biological characterization of cytolethal distending toxin (CDT), a new cytotoxin.(Tóth I.) Investigations on genome-evolution and plasticity by genome reduction. (Pósfai G.) Investigations on the mechanism of human enterobacterial infections. (Győrffy Z.) Multi-drug resistence types in Pseudomonas aeruginosa. (Szabó D.)

8. Hungarian Scientific Research Fund (OTKA) grants involving pathogenomic topics (ctnd): In vitro and in vivo pathogenomic studies on methicillin resistant and methicillin sensitive Staphylococcus aureus strains. (Rozgonyi F.) Molecular biological studies on virulence factors of bacteria causing anaerobic infections. (Nagy E.) Cytokine gene polymorphism in diseases of microbial and complex origin. (Mándi Y.) Reactivation of mycobacteria. (Miczák. A.) Genetic background of the relationship between atherosclerosis and Chlamydia pneumoniae. (Gönczöl É.)

9. Hungarian Scientific Research Fund (OTKA) grants involving pathogenomic topics (ctnd): Studies on fungal metabolism in order to develop new type antimycotic agents. (Pócsi I.) Regulation of autolytic processes in Aspergillus nidulans. (Pócsi I.)

10. Hungarian partners in international grants involving pathogenomic topics: EU FP6. Network of Excellence. European Virtual Institute for Functional Genomics of Bacterial Pathogens (EuroPathoGenomics). Coordinator: J. Hacker, University of Würzburg, Hungarian coordinator: B. Nagy. Partner 23: B. Nagy, Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest Partner 24: L. Emődy, University Medical School, Pécs EU FP6. Salmonella free broiler by live vaccine induced innate resistance to colonization and invasion and novel methods to eliminate vaccine and field strains (SUPASALVAC) Coordoinátor: P.A.Barrow CR5. partner, (WP1 leader): B. Nagy, Veterinary medical Research Institute, Hungarian Academy of Sciences, Budapest

11. Hungarian partners in international grants involving pathogenomic topics (cntd): Bilateral German-Hungarian Science and Technology Grant. (J. Hacker- L. Emődy): Studies on urinary Escherichia coli infections in order to develop new diagnostic, therapeutic and preventive measures. Bilateral German-Hungarian Science and Technology Grant. (J. Hacker- B. Nagy): Studies on virulence genes of enterotoxigenic and verotoxigenic Escherichia coli: new opportunities for prevention of disease and for increased food safety. Bilateral Austrian-Hungarian Science and Technology Grant. (F. Rozgonyi): In vitro and in vivo studies on the pathomechanism and pathogenesis of community acquired and nosocomial S. aureus infections. Bilateral British-Hungarian Science and Technology Grant. (F. Rozgonyi): Antibiotic sensitivity and molecular typing of Streptococcus pneumoniae strains isolated in Hungary.