1. 01.11.10 Lecture 1: An Introduction to Cell Biology

2. Professors Cell Biology half: Steve Rogers 422 Fordham Hall Srogers@bio.unc.edu Office hours by appointment Development half: Jason Reed 104 Coker Hall Jreed@email.unc.edu Office hours: TBA

3. Teaching Assistants Alli McMullen allison_mcmullen@med.unc.edu Kyle Grode kylegrode@gmail.com Office hours: TBA

4. Course format Lectures: MWF 11 to 11:50 AM Recitations begin January 19th and attendance is required. Students will turn in weekly problem set and TAs will go over the answers.

5. Class Website http://www.bio.unc.edu/Courses/2010Spring/Biol205- 006/http://www.bio.unc.edu/Courses/2010Spring/Biol205- 006/ Lecture notes will be posted the day before the lecture (.PDFfile) Problem sets will be posted on Friday afternoon and will be due the following week in recitation

6. Required Textbooks Essential Cell Biology, 3rd edition, by Alberts et al. (first half of the course) Principles of Development, 2nd edition, by Wolpert (second half of the course)

7. Grading Policies 4 non-cumulative exams count towards 92% of the final grade. Weekly problem sets count towards 8% of final grade. Tests will cover information in lectures, recitations, and reading assignments Make-up exams will be given only for valid reasons (medical excuses) Regrade requests must be submitted prior to the next exam

8. Policies UNC-CH honor code. All exams are to be taken without books notes, or other people and you will be asked to sign a pledge to that effect. Please turn off your cell phones during class

9. Advising for Biology Majors Degree Programs Biology General Education Requirements Bachelor of Arts in Biology Bachelor of Science in Biologyof Science in Biology Minor in BiologyMino Advising-How to find a Biology adviser find a Biology adviser Undergraduate AdvisingUnderg Abbey Fellow-Dr. Elaine Yeh yeh@email.unc.edur. Elaine Yeh y Resources Biology Majors' Manual Study Abroad Abroad Registrar's Online ServicesRegistrar's O Research Opportunities Undergraduate Research Biology Honors Programrogram Funding & OutFunding & Outreach Office of Undergraduate Researchraduate Rese Please go to the Biology Department website http://www.bio.unc.edu/Undergraduate/ to find information about:

10. What is cell Biology?

11. Divisions in the biological sciences are based on degrees of “complexity”

12. Biochemistry & Biophysics: study of the structures and behaviors of molecules

13. Microbiology: study of prokaryotic cells and viruses

14. Cell Biology: study of the structure and function of eukaryotic cells

15. Developmental Biology: study of how communities of cells form tissues, organs, and build an organism

16. Anatomy & Physiology: study of the structures and functions of tissues and organs

17. Zoology & Plant Biology: study of the organisms

18. Ecology: study of how organisms interact with each other and with their environments

19. Levels of Biological Complexity 1. Biochemistry & Biophysics 2. Microbiology 3. Cell Biology 4. Developmental Biology 5. Anatomy & Physiology 6. Zoology & Plant Biology 7. Ecology

20. Understanding cell biology is important to understand the basis for disease Hypercholesterolemia (defective uptake of lipoproteins) Cystic fibrosis (misfolding of key protein) Hypertension (defective cell-cell adhesion in the kidney) Congenital heart defects (errors in cell migration during development) Myscular dystrophy (defective attachment of the plasma membrane to the cytoskeleton) Lysosomal storage disease (defective intracellular transport of enzymes) Food-borne illness (Salmonella, E. coli) Cancer (errors in cell division, migration, cell polarity, growth, etc) Ageing All disease states are caused at the cellular level

21. Understanding cell biology is important to make informed decisions on social issues Genetic engineering of foods Biotechnology Organ growth in culture Stem cell research Forensic sciences Archaeology