1. Bioinformatics + The Human Genome Project Teacher Conference Friday October 19 th, 2007

2. February 2001: Completion of the Draft Human Genome Public HGP Celera Genomics A p r i l 1 4, 2 0 0 3 : T h e H u m a n G e n o m e i s c o m p l e t e d – a g a i n ! O c t o b e r 2 0 0 4 - p r e s e n t : T h e H u m a n G e n o m e i s n o w r e a l l y f i n i s h e d ! The Human Genome Project

4. To carry the sequence of my genome in my pocket, I need: (a) supercomputer (b) my laptop (brand new) (c) my home computer (Oops, it’s old) (d) DVD (e) CD (e) zip disk (f) floppy disk If compressed, the 3GB human genome will also fit on a single CD

5. The Human Genome…By the Numbers 75-100 trillion…Cells in the human body 3.1 billion…Base pairs in each cell 2.4 million…Base pairs in the largest human gene 28,000-35,000…Genes in the human genome 46…Chromosomes in each cell

6. Technology

7. What is Bioinformatics?

9. maps.google.ca

10. Let’s Look at the Human Genome...

11. Websites visited during this Bioinformatics 101 Workshop Google www.google.cawww.google.ca Google Maps http://maps.google.cahttp://maps.google.ca UCSC Human Genome Browser Gateway –http://genome.ucsc.edu/cgi-bin/hgGatewayhttp://genome.ucsc.edu/cgi-bin/hgGateway (hint: use google to look up “Genome Browser”)

12. Image Credits DNA with Features –Image credit: Genome Management Information System, Oak Ridge National Laboratory; Available from: http://genomics.energy.gov/gallery/ http://genomics.energy.gov/gallery/ Human Genome Project - Science cover –Image credit: Ann Elliott Cutting; Available from: http://www.sciencemag.org/content/vol291/issue5507/cover.dtlhttp://www.sciencemag.org/content/vol291/issue5507/cover.dtl Human Genome Project - Nature cover –Image available from: http://www.nature.com/nature/journal/v409/n6822/index.htmlhttp://www.nature.com/nature/journal/v409/n6822/index.html What is Bioinformatics? –Image credit: Jiang Long; Available from: http://www.scq.ubc.ca/what-is-bioinformaticshttp://www.scq.ubc.ca/what-is-bioinformatics Science@NASA universe logo –Image available from: http://science.hq.nasa.gov/universe/images/universe_09.jpghttp://science.hq.nasa.gov/universe/images/universe_09.jpg 1960 Film Projector –Image available from: http://en.wikipedia.org/wiki/Slide_projectorhttp://en.wikipedia.org/wiki/Slide_projector iPod nano –Image available from: http://www.apple.com/ipodnano/http://www.apple.com/ipodnano/ Downtown Bus Route map –Available from: http://translink.bc.ca/http://translink.bc.ca/ MSL and nearby coffee shops at UBC map –Available from: http://maps.google.ca/http://maps.google.ca/ A view of the Leptin Precusor Gene in the UCSC Genome Browser –Available from: http://genome.ucsc.edu/cgi- bin/hgTracks?hgsid=98731626&hgt.out1=1.5x&position=chr7%3A127669698-127691768http://genome.ucsc.edu/cgi- bin/hgTracks?hgsid=98731626&hgt.out1=1.5x&position=chr7%3A127669698-127691768