1. Chromosomal Inheritance and Human Sex Determination

2. Chromosomes!

3. Is this what Mendel would expect?

4. Is this what Mendel would expect?

5. Practice Question: Chromosomal Inheritance
If a color blind man has a child with a “wild-type” woman, what are the chances that this daughter of theirs will be colorblind?
What are the chances that their son will be colorblind?
Can females be colorblind? What would the genotype of the parents have to be?

6. Human Sex Determination
Textbook Story:
XX = Female
XY = Male
With a few exceptions….

7. Occasionally, chromosomes fail to sort correctly resulting in aneuploidy (unusual numbers of chromosomes)

8. Aneuploidy can also occur with Sex Chromosomes
XXY = Klinefelter Syndrome- phenotypically male with normal intelligence, sterile
XO = Turner syndrome- phenotypically female, sterile, usually normal intelligence
XYY = no general traits (tall)
XXX = healthy, “normal”

9. The SRY Gene

10. Hormonal Signaling is Complex

11. Hormone Production is Complex