1. Presented by ORNL–University Partnerships in Computational Biology Igor B. Jouline Joint Institute for Computational Sciences The University of Tennessee–Oak Ridge National Laboratory

2. 2 Jouline_Bio_0611 ORNL–University partnerships in computational biology Biosciences Division Computer Science and Mathematics Division Biosciences Division Computer Science and Mathematics Division Joint Institute for Computational Sciences School of Biology College of Computing Center for Bioinformatics and Computational Biology School of Biology College of Computing Center for Bioinformatics and Computational Biology Graduate School of Genome Science and Technology Joint Institute for Biological Sciences

3. 3 Jouline_Bio_0611 ORNL–UT Graduate School of Genome Science & Technology Structural Biology and Proteomics Genetics and Genomics http://gst.ornl.gov Areas of Research and Education: Computational Biology and Bioinformatics

4. 4 Jouline_Bio_0611 Protein sequences Domain architectures MiST: Microbial Signal Transduction Database Modular Perl infrastructure XML SQL Linux Genomes Meta- genomics (in progress) HHMER SMART libraries Pfam libraries Signal transduction families signatures Signal transduction families — MiST Web interface http://genomics.ornl.gov/mist PostgreSQL relational database management system

5. 5 Jouline_Bio_0611 MiST: Visualization of signal transduction profiles in 176 microbial genomes http://genomics.ornl.gov/mist

6. 6 Jouline_Bio_0611 Distribution of sensory (a) and regulatory (b) domains in microbial genomes Ulrich et al. (2005) Trends Microbiol

7. 7 Jouline_Bio_0611 Computational microbial genomics: Poison + water = hydrogen "The findings show the continued value of microbial genome sequencing for exploring the useful capabilities of the vast realm of microbial life on Earth," says Ari Patrinos, former director of the Office of Biological and Environmental Research, part of the U.S. Department of Energy's (DOE) Office of Science. DOE, which funded the study, is pursuing clean fuel technologies. www.sciencedaily.com/releases/2005/12/051204103616.htm Life in Hot Carbon Monoxide: The Complete Genome Sequence of Carboxydothermus hydrogenoformans Z-2901 Martin Wu, Qinghu Ren, A. Scott Durkin, Sean C. Daugherty, Lauren M. Brinkac, Robert J. Dodson, Ramana Madupu, Steven A. Sullivan, James F. Kolonay, William C. Nelson, Luke J. Tallon, Kristine M. Jones, Luke E. Ulrich, Juan M. Gonzalez, Igor B. Zhulin, Frank T. Robb, and Jonathan A. Eisen

8. 8 Jouline_Bio_0611 Contacts Igor B. Jouline (Zhulin) PhD. Joint Institute for Computational Sciences The University of Tennessee — Oak Ridge National Laboratory Associate Professor The University of Tennessee UTK (865) 974-7687 Ijouline@utk.edu Ijouline@utk.edu Senior R&D Staff Member Oak Ridge National Laboratory ORNL (865) 241-3697 joulineib@ornl.gov 8 Jouline_Bio_0611