1. ©CMBI 2005 Bioinformatics New Integrating Across borders Problem oriented Theory and practice Not very difficult…

2. ©CMBI 2005 Bio + informatics

3. ©CMBI 2005 Bioinformatics examples Analysis of the information content of genomes Sequence analysis and sequence alignment Most computational aspects of drug design Data mining in biological databases Model macromolecular structures/complexes Biological pathway analysis Phylogeny

4. ©CMBI 2005 The human genome

5. ©CMBI 2005 Human genome....acccaa gaagtcagaa tcctcgaagc tgaagcctga ctgtaagctc tgcctcctac aactagacaa gtcacaatgc aacccctttg ctccagagga aaaggagtaa gcacagaggg cttctgagtc cggcaatgct ccatttcctg acaggagcat tttacagact tgcgtctgcc cctctgaggg aggcagggcc atcagctaac actcagagac aaggatggtc ctacaacatc ctgatctggg aggaagaggt gaaggcaact caccaccctc aggcatctta acagaaaaca gtggaactaa ggctcattct aaagaatgtg cccaagatca cacaccgaag gctgcaaagc gagagtcaaa cttggaaccc tgaacctgca cttgtccctt tacactgccc tgcagcatgg atgcgatggc tgggcagagg gaagtgccca agcctgggga caaaaatgcc tacctg....

6. ©CMBI 2005 Genome annotation

7. ©CMBI 2005 Bioinformatics and medicine The human genome will be known and properly annotated in a few years. At that moment we know nearly all targets for medicines.

8. ©CMBI 2005 Chromosomes

9. ©CMBI 2005 Goals for medicine and pharma

10. ©CMBI 2005 Bioinformatics and medicine Parasite Active site

11. ©CMBI 2005 Bioinformatics and medicine

12. ©CMBI 2005 GPCR: Thé target for drug design

13. ©CMBI 2005 Drug Design

14. ©CMBI 2005 Single Nucleotide Polymorphism SNPs (“snips”): Naturally occurring variants that affect a single nucleotide. Occurrence: once in every 300-1000 bases. SNPs are responsible e.g. for hair colour, but are also the reason for individual differences in respons to drugs.

15. ©CMBI 2005 Plant/Animal improvement

16. ©CMBI 2005 Protein engineering

17. ©CMBI 2005 Molecular graphics If you don't think that pictures are the best way to communicate, I suggest you go home, and watch your radio.

18. ©CMBI 2005 Molecular graphics

19. ©CMBI 2005 Molecular graphics Some mutations found in the P63 model reduce its DNA binding capacity P63 is a P53 homologue

20. ©CMBI 2005 Data and databases

21. ©CMBI 2005 Sequences Sequence alignment is the best tool for transferring information from a well studied molecule to a novel, unknown, or less well studied molecule. And this topic, transfer of information, will be the main topic of this course.