2. 1,000,000,000 7,000,874 6587 423 8 1 US $ investment hours of work experiments researchers years drug Pharma is experience challenges

3. Pharma R&D is adapting for the future Focus is on: Productivity, ROI Externalization & Collaboration Diversification Personalized Medicine We want to contribute Dedicated Science, Medical Information company 7,000 Employees PhD scientists, information scientists, publishers Extensive scientific network 600,000 authors 300,000 reviewers 70,000 journal editors and board members Publish 300,000 articles/yr 2,000 journals 20,000 books Leading titles (e.g. Cell, The Lancet) Global STM coverage 18,000 titles used in abstracting, indexing Extensive patent coverage (USTPO, EPO, WPO)

4. Our information spans Pharma’s value chain Target Validation Lead ID Lead Validation PoC Phase I Phase II Phase III Phase IV ToxicitySafety Post Launch Target Finding Trusted External R&D

5. Evolving with Pharma R&D I.Identify relevant knowledge that drives R&D II.Disseminate content to scientists, R&D decision makers III.Make content interactive and actionable Creating Insight

6. Identify relevant content that drives R&D... the past... the present

7. ... the past Disseminate Content to Scientists, R&D decision makers... the present

8. ... The past Make Content Interactive and Actionable... The present

9. Why is Elsevier here? Novartis announces USD 1 billion investment to build largest pharmaceutical R&D institute in China Press Release November 2009 Because our customers have come here....... And our new customers are here

11. What is Reaxys? A workflow solution for researchers in chemistry, drug discovery and related scientific areas Using Reaxys researchers can Easily access validated reaction and substance data, ranking and filtering for relevant results Source available chemicals Plan and optimize synthetic route Export and share results for immediate action in the lab An extensive repository of reaction and substance property data, Reaxys includes: Organic, inorganic, organometallic chemistry from 400 journals Coverage from 1771 - present World Patent Office, European Patent Office and US English language patents from the major chemistry patent classes

12. Reaxys extracts valuable chemical properties and reaction details from journals and patents. 1H NMR 300 MHZ

13. Five good reasons to use Reaxys 1.The wealth of experimentally validated data which can be searched, filtered and ranked to find the most relevant answer to a specific question quickly. 2.Functionality beyond data searching: synthesis planner, results management, smart analysis tools for fast evaluation. 3.No user or usage limits: flat-rate for institution-wide access at any time. 4.The intuitive interface and online educational material help reduce your training efforts. 5.Interoperable: linking to SciVerse Scopus, full- texts at publishers and patent offices. Access to your own library settings via OpenURL resolver is possible. Professor Peter Johnson, University of Leeds

14. What our customers say: Peter Johnson, University of Leeds Reaxys is used by 24 of the Top-25 * ranked academic chemistry research programs Src: 2011 www.arwu.org

16. Reaxys Case Study: Finding coumarin glycosides

17. What we will do Search by structure Filter By substructure, spectra, and bioactivity Export to a spreadsheet Create a Synthesis Plan Use the Form-based and Advanced Search Tabs Search by Keyword 17

18. HO O Examples: Isolate the substances that have NMR data and antibacterial activity Find coumarin glycosides O O O O O O

22. coumarin

25. glucopyranose 5

27. *bac*

39. antibac bacterio

41. catalyst *’ palladium

42. Reaction type hydrogenation

45. Coumarin NEXT glycoside C*marin* NEXT glycosid*

47. What you have seen Search by structure Filter By substructure, spectra, and bioactivity Export to a spreadsheet Create a Synthesis Plan Use the Form-based and Advanced Search Tabs Search by Keyword 47

48. Thank You Reaxys training materials can be found at www.reaxys.com/infowww.reaxys.com/info Contact Reaxys Customer Support at: Usinfo@reaxys.com if you would like to schedule a Reaxys Advanced Training webinarUsinfo@reaxys.com

49. Thank you Questions?