1. Total synthesis of solanoeclepin A
何玉萍

2. a, Potato cyst nematode Globodera rostochiensis
a, Potato cyst nematode Globodera rostochiensis. b, Cysts on potato roots, which protect the nematodes until hatch stimulants produced by the host plant are present. c, Potato field affected by potato cyst nematodes.

3. stereoselective
Simmon-Smith reaction
Coupling reaction G E D
based-induced
intramolecular cyclization F C A B
intramolecular
Diels-Alder
reaction

4. Meinwald
rearrangement
Sharpless 环氧化反应

5. Meinwald rearrangement
Pd(0)/PR3 (5 mol %), Bi(OTf)3·xH2O (0.1 mol %), IrCl3·xH2O (1 mol %), and Er(OTf) (1 mol %) hydrgeon migration
CrTPP(OTf), (1 mol %), CrTBPC(OTf ) , (1 mol %) alkyl migration

6. J . Am. Chem. Soc.,1958, 80, 6303
Tetrahedron Letters, 2003, 44 , 7687
J. Am. Chem. Soc. 2004, 126, 9554
Chem. Commun., 2009, 1255

8. Simmons–Smith reaction
J. Am. Chem. Soc. Vol. 120, No. 46, 1998,11945

9. mechanism J. Org. Chem., Vol. 40, No. 7, 1975

11. mechanism

13. Hiyama Coupling

16. 配体交换 扭转 消除

19. solanoeclepin A