1. A Presentation to the University of Nebraska Medical Center Federal Funding Opportunities Workshop The Implementation Group, Inc. December 13-14, 2005

2. Outline Overview and Objectives Federal R&D Overview UNMC R&D Analysis Federal Funding Opportunities The National Science Foundation National Aeronautics and Space Administration Department of Energy Merit Review and Proposal Development

3. TIG Overview

4. The Implementation Group, Inc. (TIG) TIG is a full-service consulting firm that assists educational institutions, organizations and corporate entities to target, capture and implement U.S. government and private sector contracts and grants. Established: 1994 Location: Washington, DC

5. TIG: Services TIG’s service offerings are focused on the full life cycle of activities associated with being successful in the federal grants and contracts arena. They include: Capability Assessments and Strategic Planning Intelligence Gathering Opportunity Identification and Qualification Partnership Formation Liaison with federal officials and private sector funders Proposal Development and Proposal Enhancement Project Implementation Troubleshooting

6. TIG Partnership with the UNMC

7. UNMC/TIG Partnership To assist UNMC to increase its competitiveness for federal research and training grants, with emphasis on non-NIH funding. Areas of work: Assessment and Analysis Conduct SWOT analysis Infrastructure Improvement Agency Assistance/Opportunity Identification Identify and assist UNMC in pursuing federal grant opportunities particularly at the NSF Proposal review and development Project implementation assistance

8. Visiting Team The Implementation Group, Inc. Joseph G. Danek, Ph.D. Senior Vice President and Chief Operating Officer Jennifer C. Danek, M.D. Consultant National Science Foundation Christopher Greer, Ph.D. Program Director, Frontiers in Integrative Biological Research (FIBR), Directorate for Biological Sciences

9. Specific Goals of Visit  Review federal funding opportunities at the NSF, DOE, and NASA particularly in the life sciences  Learn more about UNMC R&D capabilities and priorities  Identify (with faculty) the strengths and weaknesses in obtaining funding  Match funding opportunities to interests of faculty groups  Develop a preliminary proposal development plan  Assist UNMC in executing plan

10. Current Climate

11. Key Budget and Economic Points The Recent Past To date, the United States has allocated $351 billion for military operations, security and reconstruction costs in Iraq and Afghanistan. The U.S. Congress approved roughly $70 billion in emergency spending for disasters. The Immediate Future The FY2006 Defense Appropriations Bill contains an additional $50 billion for military operations, security and reconstruction costs in Iraq and Afghanistan. There is an additional $100–200 billion in emergency spending for the recent disasters. “Baby Boom” retirement era will give rise to much larger annual Medicare expenditures. Escalating costs associated with maintaining the Federal debt.

12. Spending America’s Income Broad revenue and spending categories in President Bush’s fiscal 2005 budget: Where it comes from (receipts) $2.1 trillion How it would be spent (outlays) $2.4 trillion Individual income tax: $874 billion Corporate income tax: $230 billion Payroll tax: $794 billion Excise tax: $73 billion Estate and gift tax: $21 billion Customs duties: $22 billion Other: $37 billion $510 billion: Social Security $490 billion: Discretionary (non-defense) $420 billion: National defense (discretionary) $290 billion: Medicare $178 billion: Interest on debt $188 billion: Medicaid $320 billion: Other Deficit: $345-$360 billion (with adjustment for revenue uncertainty) $2.4 trillion

13. Defense Energy Agriculture Transportation Education Justice Housing &Urban Development EPA NRC NSF Veterans Affairs Labor NASA Departments & Agencies Development of the Federal R&D Budget Showing Fields of Science and Executive and Legislative Decision Units Engineering Physical Sciences Environmental Sciences Life Sciences Psychology Social Sciences Other Sciences Fields of Science National Defense Affairs International Energy Agriculture Transportation Health Budget Review Offices (OMB) House & Senate Budget Committees (Budget Functions) Agriculture & Related Agencies Commerce, Justice, State, Judiciary Energy and Water Development Foreign Operations VA-HUD-Inde- pendent Agencies Interior Labor, Health & Human Services, & Education Transportation & Related Agencies Defense House and Senate Appropriations Subcommittees Armed Services Labor and Human Resources Banking, Housing & Urban Affairs Foreign Relations Veterans Affairs Senate Authorization Committees Energy & Natural Resources Environment & Public Works Commerce, Science, & Transportation National Security Economic & Educational Opportunities Banking & Financial Affairs International Relations Veterans Affairs Commerce Resources Transportation & Infrastructure Science Agriculture Agriculture, Nutrition, & Forestry House Authorization Committees (With significant R&D $) Judiciary International Science, Engineering and Technology National Security Science Technology Math & Computer Science Agency for International Development Commerce Health & Human Services Interior National Security & International Affairs Natural Resources, Energy, and Science Economics & Government Human Resources, Veterans, and Labor General Science, Space & Technology Natural Resources & Environment Commerce & Housing Credit Community & Regional Development Education, Training, Employment, & Social Services Veterans Benefits & Services Administration of Justice National Science and Technology Council Research Committees Connecting lines indicate location of agency budget decisions, but not decision sequences. Environment and Natural Resources Environment and Natural Resources

14. R&D in the FY 2006 Budget

15. Total R&D by Agency: FY 2006 Proposed Budget Authority in billions of dollars Source: AAAS, based on OMB R&D Budget Data and agency estimates

16. R&D in the FY 2006 Budget Federal R&D at all-time high of $132 billion this year, but would barely increase (0.1%) in 2006. In FY 2006, federal research funding would fall 1.4 percent to $54.9 billion The FY 2006 budget represents a downward shift from recent trends Cuts across the federal R&D portfolio NSF: most research directorates would stay flat for three years. Steep cuts proposed to education programs. NIH: budget would increase just 0.5 percent. RPG success rate would fall to 21 percent. USDA: boosts for competitive grants, but cuts to formula funds.

17. FY 2006 R&D Appropriations (as of 11/05)

18. Other Agency Funding for Life Sciences: $4.3B (14% of total budget) in 2005 Life Sciences Portfolio, Total - $29 billion HHS – 86% (25.5 billion) Other – 14% ($4.3 billion) - USDA – 34% ($1.4B) - NSF – 13% ($578M) - DoD – 16% ($695M) - DoE – 7% ($289M) - NASA – 8% ($334M) - Other – 22% ($953M)

19. “Life Sciences” Research Dollars as Percentage of Total Agency Budget: $29.8B Source: http://www.nsf.gov/statistics/infbrief/nsf06300/tab4http://www.nsf.gov/statistics/infbrief/nsf06300/tab4

20. UNMC R&D Portfolio

21. UNMC - Federal obligations for science and engineering research and development (R&D) to universities and colleges, by state, institution, and agency: FY 2002 [ dollars in thousands], Source: National Science Foundation, Division of Science Resources Statistics, Federal Science and Engineering Support to Universities, Colleges, and Nonprofit Institutions: Fiscal Year 2002 (Table B-17): Arlington, VA (NSF 05-309) [March 2005]

22. UNMC as Percentage of Total State Fed. Obligation for S&E R&D In FY 2002, Nebraska had no ARC, DoT, HUD, Labor, NRC, OJP, or SSA funding. National Science Foundation, Division of Science Resources Statistics, Federal Science and Engineering Support to Universities, Colleges, and Nonprofit Institutions: FY 2000

23. Fed. Obligations for R&D – All Agencies

24. Fed. Obligations for R&D - NIH

25. Fed. Obligations for R&D - DoD

26. Fed. Obligations for R&D - NSF

27. UNMC Federal Obligations for R&D

28. Summary Analysis (1993 – 2002)  Overall Growth: UNMC overall federal R&D growth outpaced growth across all institutions  NIH: UNMC federal R&D is dominated by NIH (85% - 95% of total)  DoD: UNMC shows sporadic peaks in DoD but no consistent growth despite DoD growth across all institutions  NSF: UNMC shows no consistent growth patterns at NSF

29. Comparison to Peer Institutions

30. Comparison to Peer Institutions cont.

31. Conclusion The Pot 'O Gold! Opportunities exist for UNMC at NSF, DoE, NASA, and other agencies

32. National Aeronautics and Space Administration

34. FY 06 NASA By The Numbers Total: $16.4 billion (+ 1.3%) R&D: $11.5 billion (+ 7.3%) Science, Aeronautics, and Exploration (SAE): $9.7 billion (+7.6%) Biological/Life Sciences: $500 million (est.)

35. Cuts to NASA’s Research Portfolio  Aeronautics research portfolio : -down 2.5 percent to $938 million  Earth Sciences : -down 7.3 percent to $2.1 billion  Biological and Physical Sciences : -down 13.6 percent to $799 million -NASA is dramatically restructuring and downsizing its biological and physical sciences research portfolio into a Human Systems Research and Technology program more narrowly focused on research topics relevant to human space flight.

36. OBPR Headquarters Organizational Chart

37. OBPR Enterprise Strategy Five organizing questions are the basis for the Biological and Physical Research Enterprise Strategy: 1. How can we assure the survival of humans traveling far from Earth? 2. How does life respond to gravity and space environments? 3. What new opportunities can research bring to expand understanding of the laws of nature and enrich lives on Earth? 4. What technology must we create to enable the next explorers to go beyond where we have been? 5. How can we educate and inspire the next generation to take the journey?

38. Biological/Life Sciences Research Estimated budget: $400 million in FY06 Supports safe human presence in space Research to control space flight risks to humans from radiation, reduced gravity, and isolation Pursues fundamental biological questions from cell to tissues to organisms to ecosystems which produce results that support Methods enabling human explorations of space; Understanding of biological systems; and Improving human health on Earth

39. Fundamental Space Biology Division Goals: Use microgravity and other space effects to enhance understanding of biological processes Develop foundation of biological knowledge Research Elements: Molecular structures and physical interactions, Molecular biology, Cell biology, Evolutionary biology, Gravitational biology, Developmental biology, Organismal and comparative biology

40. Bioastronautics Research Division Goals: Set priorities for issues related to flight crew health and med. technology, and fundamental and applied research Sponsor research to address flight medical safety and performance issues Integrate science and medical research Research Elements: Space Biomedical Research Areas: Biomedical physiology, Behavior and performance, Group dynamics, Radiobiology, Space and human factors engineering, Space medicine, Flight crew health care delivery and systems, Human clinical and space medical research Spacecraft Habitability, Planetary Habitat, Environmental Health, and Space Systems Technology: Advanced life support, Toxicology, microbiology, Advanced EVA, Radiation protection, Bioplex This division also manages the National Space Biomedical Research Institute: Countermeasures development

41. Office of Health and Medical Systems Dr. Richard S. Williams Biography Space and Life Sciences Directorate Bioethics and Transition to Practice Division Mission for Health Care  The Chief Health and Medical Officer assists the Administrator to ensure the health and safety of NASA employees in space and on the ground.  The Chief Health and Medical Officer also monitors human and animal research and clinical practice.

43. Department of Energy

46. DoE FY 2006 Budget Final DOE budget at $8.7 billion for R&D activities, a slight increase of 0.9 percent DOE’s Office of Science receives a modest 0.6 percent increase in its R&D portfolio to $3.4 billion includes $130 million in congressional earmarks and a boost in computing research.

47. DOE Organizational Chart

48. DoE Office of Science Flat budget for the last decade Director’s mission is to secure additional funding and support Primary source of support for the Physical Sciences 42% of federal support to physical sciences Primary support to: high energy physics, nuclear physics, nuclear medicine, heavy element chemistry, plasma physics, and magnetic fusion, and catalysis Manages multidisciplinary science programs Directly supports 23, 400 Ph.D.s, Post Docs, and Graduate students Constructs and operates large scientific facilities

49. Office of Science’s Biological and Environmental Research (BER) Program Advancing environmental and biomedical knowledge Supports fundamental research in: Climate change Environmental remediation Genomics Systems biology Radiation biology Medical Sciences Supports leading edge research facilities across a range of disciplines Coordinates research across all programs

50. Biological and Environmental Research (BER) Long-Term Goals Life Sciences: Life Sciences: Characterize the multi protein complexes involving a scientifically significant fraction of a microbe’s proteins. Develop computational models to direct the use and design of microbial communities to clean up waste, sequester carbon, or produce hydrogen Medical Applications and Measurement Science: Medical Applications and Measurement Science: Develop intelligent biomimetic electronics that can both sense and correctly stimulate the nervous system

51. Office of Science’s Biological and Environmental Research (BER) Staff Dr. Aristides Partinos, Associate Director, BER and Acting Director, Life Sciences Division 301-903-5051 ari.partinos@science.doe.gov Dr. Mike Viola, Director, Medical Sciences Division 301-903-0567 Michael.viola@science.doe.gov

52. Office of Science’s Biological and Environmental Research (BER) Merit Review System All projects undergo regular peer review and evaluation Provides independent assessment of scientific and/or technical merit of the research Basic Review Standards Sufficient technical/scientific content and merit Completeness Program policy and priorities

54. Summary: Trends in Federal R&D over the Last Decade  Big science has hit the life sciences  All scientific fields are now clearly inter-dependent  No longer such a thing as “disciplinary science”  Technology is now driving science, more than the reverse  Significant increases in new term not likely

55. The Implementation Group, Inc. 101 Constitution Avenue, NW Suite 650 East Washington, DC 20001 202.639.0671 – tel 202.639.0713 – fax