1. Epidemiology of Diabetes Mellitus(DM) in Siberia Eugene ShubnikovEugene Shubnikov, MD Eugene Shubnikov Center for Endocrinology «SibDiab» Novosibirsk, Russia readings

2. Objectives n To Outline the Incidence of Type 1 DM among Children in Novosibirsk Area, Russia n To Describe the Prevalence of DM and Impaired Glucose Tolerance (IGT) among Adult Population of Novosibirsk City, Russia. n To Discuss the Prevalence of DM among Native Polulation of Chukotka Pepublic of Russia.

3. Map of Russia Novosibirsk Chukotka Moscow SIBERIA

4. Siberian IDDM Registry n Case Identification is Based on: n 1. Review of Hospital Records at Novosibirsk City’s Hospitals n 2. Review of Out-Patient Clinic’s Data at Novosibirsk City

5. Siberian IDDM Registry n Consists of: n Novosibirsk Area IDDM Registry n Novosibirsk City IDDM Registry

6. Novosibirsk District Novosibirsk area-178 300 sq.km. Novosibirsk City 477 sq. km.

7. Incidence of IDDM per 100000 Children before Age of 15 for 1980-1996

8. Incidence of IDDM by Age Groups

9. Time Trends in IDDM Incidence

10. Family History Information n From 715 Cases Diagnosed before Age 15, our Data Base Includes Information on: n 19 Families where Child and One Parent Suffer from IDDM n 10 Families where Two Siblings Suffer from IDDM

11. Hypothesis n Taking into Account Small Number of Multiplex Families, the Increase in Risk at Puberty and Increasing IDDM Incidence, we Suppose that Some Unknown Casual Agents are Playing an Important Role at IDDM Pattern in Siberia

12. Map of Russia Novosibirsk 1 2

13. Prevalence of DM According to Screening Data n First Standardized Study of a Representative Sample of Russian Men and Women 25-64 years in Novosibirsk City in the Frame of WHO «MONICA» Project. WHO «MONICA» Project WHO «MONICA» Project n 1985 WHO Criteria for Diagnosis of DM and IGT n Data was Compared to DM Registry Data at the same Area

14. The Prevalence Estimates for IGT and DM in Per Cent

15. The Prevalence Estimates for Previously Diagnosed and New Cases of DM

16. CHUKOTKA ALASKA

17. Number of DM Patients among Chukotka Native Population Number of Cases Years

18. SIRENIKI NEW CHAPLINO ANRAKINNOT LORINO

19. Prevalence of DM among Chukotka Natives According to Screening Data n We Confirmed just One Case of DM in an Eskimo Woman(Diagnosed Previously) during the Screening, that was 0,5% of Examined Female Population. n There were no DM Cases in Examined Male Population.

20. The Age Distribution of IGT Prevalence among Chukotka Natives

21. Owerweigh among Chukotka Natives (Screening Data) n Body Mass Index (BMI) was Greater than 29 among 8,3% of Men and 29,4% of Women. n There were 17,9% of Men with BMI Greater than 27 and 55,6% Women with BMI Greater than 25.

22. Changes in Diet among Chukotka Native Adults during 10 years Farida R.Mamleeva et al., 1996 In per cent (%)

23. Conclusion n According to Our Investigations, the Incidence and Prevalence of DM in Siberia are Relatively low, Compare to other European and World Populations. n We have Revealed the Increasing of DM Incidence and Prevalence at all Siberian Regions which Reflects Global DM’s Tendency.