1. Smaller populations, larger frequency change? What about allele size effects What about environmental variation Are large populations limited to one peak Population size and long-term selection

2. - Assuming h2m low, most response reflects standing genetic variation - Selection fixes favorable alleles, drifts fixes alleles at random - Inbreeding depression lower in large pop (Ne arguments) - Natural selection more effective - Larger variety of recombinants in large pop - Large pop are more likely to fix alleles ameliorating bad alleles - Mutation will supply needed modifiers in numbers proportional to population size But Hidden Epistatic potential??

6. Huge population sizes in an artificial selection expt.

7. Artificial selection not Opposed by Natural selection in Large population

8. Large Populations: Selection is a more efficient extractor of the improbable