1. Oral Biology 5670 Bone growth and development Bone biology Educational objectives –Exposure to basic concepts of bone biology –Correlation of basic bone biology to clinical treatment –Special considerations / implications of bone biology to dentistry

2. Clinical Correlates of Bone Growth and Development Facial skeletal development Maxillary development Mandibular development

3. Clinical Correlates of Bone Growth and Development Effect of congenital anonalies on facial growth and development Effect of surgical correction of congenital anomalies on facial growth and development Tooth development and retention influence on alveolar bone levels

4. Clincal Correlates of Bone Growth and Development Orthodontic tooth movement Bone healing following tooth extraction Bone response to alloplastic materials Bone healing in approximation of dental implants

5. Clinical Correlates of Bone Growth and Development Bone grafting to treat dentoalveolar defects Bone grafting to treat discontinuity defects Fracture healing

6. Cellular Growth Hypertrophy Hyperplasia Secretion of extracellular material Interstitial growth

7. Embryologic Type of Bone Endochondral Intramembranous

19. Functional Matrix Theory of Growth “Growth of the face occurs as a response to the functional need and is mediated by the soft tissue in which the bone is embedded” Soft tissues grow, bone and cartilage react

20. Growth Control Bone is the determinant of its own growth Cartilage is the determinant of bone growth Soft tissue matrix is the determinant of growth

26. Orthodontic Tooth Movement Bone apposition and resorption Effects on the pulp Effects on the PDL Effects on the tooth root

29. Effects of Periosteum Provision of undifferentiated mesechymal cells Envelope to limit/regulate bone apposition

30. Introduction 10 y.o. female 12/98 CC: –Noticed swelling in face on left side for two weeks HPI: –Facial swelling –Left lower lip “tingles” –No pain or change in bite

31. Examination Left lower facial swelling, without thrill/bruit Lower vestibular swelling, L>R No abnormal tooth mobility Teeth 19-28 vital with EPT CN II-XII grossly intact

32. Assessment Problem list: –Multilocular radiolucent lesion –Teeth vital without resorption, displacement, or mobility –Apparent cortical expansion Diff. Dx: –Central Giant Cell Lesion –Ameloblastomic Fibroodontoma –Ameloblastoma

33. Treatment Plan Impressions for splint fabrication Screening labs Ca, alk phos, PTH –All WNL CT of mandible: –Multilocular radiolucents, from infer border to encompass tooth roots superiorly –Buccal and lingual cortices intact, although expansion present Incisional bx