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CHMI 2227 - E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Levels of Protein Structure - Conformation of Peptide Group.

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Presentation on theme: "CHMI 2227 - E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Levels of Protein Structure - Conformation of Peptide Group."— Presentation transcript:

1 CHMI 2227 - E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Levels of Protein Structure - Conformation of Peptide Group

2 CHMI 2227 - E.R. Gauthier, Ph.D.2 Proteins: Levels of Protein Structure http://macromolecules.ucsf.edu/Lectures/Tanja%20Macromol_forces%202006.pdf

3 CHMI 2227 - E.R. Gauthier, Ph.D.3 Primary Structure http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf

4 CHMI 2227 - E.R. Gauthier, Ph.D.4 Secondary Structure http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf

5 CHMI 2227 - E.R. Gauthier, Ph.D.5 Tertiary Structure http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf

6 CHMI 2227 - E.R. Gauthier, Ph.D.6 Quaternary Structure http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf

7 CHMI 2227 - E.R. Gauthier, Ph.D.7 Proteins

8 CHMI 2227 - E.R. Gauthier, Ph.D.8

9 9 Secondary Structure of Proteins http://employees.csbsju.edu/hjakubowski/classes/ch331/protstructure/olunderstandconfo.html

10 CHMI 2227 - E.R. Gauthier, Ph.D.10 Conformation of the Peptide Group Peptide Group

11 CHMI 2227 - E.R. Gauthier, Ph.D.11 Peptide bond has resonance structures! Peptide bond is shown as single C-N bond Peptide bond is shown as a double bond

12 CHMI 2227 - E.R. Gauthier, Ph.D.12 Conformation of the peptide group Figure 3.25 Biochemistry 2001, Fifth Edition

13 CHMI 2227 - E.R. Gauthier, Ph.D.13 Cis conformation of the peptide group R2 R1 CαCα CαCα CN O H

14 CHMI 2227 - E.R. Gauthier, Ph.D.14 Trans conformation of the peptide group CαCα CαCα R1 R2 N H C O

15 CHMI 2227 - E.R. Gauthier, Ph.D.15 Exceptions to the rule! Figure 3.26 Biochemistry 2001, Fifth Edition

16 CHMI 2227 - E.R. Gauthier, Ph.D.16 Psi and Phi Angles

17 CHMI 2227 - E.R. Gauthier, Ph.D.17 Psi and Phi Angles Peptide Bond

18 CHMI 2227 - E.R. Gauthier, Ph.D.18 Psi and Phi Angles

19 CHMI 2227 - E.R. Gauthier, Ph.D.19 Animation of Phi rotation Phi rotation http://employees.csbsju.edu/hjakubowski/classes/ch331/protstructure/olunderstandconfo.html

20 CHMI 2227 - E.R. Gauthier, Ph.D.20 Animation of Psi rotation Psi rotation http://employees.csbsju.edu/hjakubowski/classes/ch331/protstructure/olunderstandconfo.html

21 CHMI 2227 - E.R. Gauthier, Ph.D.21 Ramachandran Plot

22 CHMI 2227 - E.R. Gauthier, Ph.D.22 Ramachandran Plot Figure 3.28 Biochemistry 2001, Fifth Edition

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