1. Introduction and benefits Paul Peters 31 Jan 2007 Tubitak: MAM Research Center

2. 2006 Edition Strategies & challenges within pharma & biotech Companies searching for more complex solutions in healthcare Need to develop strong clinical candidates –adopt best practices from both traditional pharmaceutical as well as modern biotechnology –Major attrition in development, especially Phase 2 Chemistry and biology merging as sciences (genomics, proteomics) Freedom-to-operate and other intellectual property issues are key drivers of R&D Strategic information has become a critical business factor to innovate

3. 2006 Edition CAS... we are scientists, creating and delivering the most complete and effective digital information environment for scientific research and discovery CAS is a self-sustaining division of the American Chemical Society CAS employs 1250 staff members in Columbus, Ohio Chemical Abstracts Service, CAS

4. 2006 Edition CAS Content... the world’s largest collection of chemical and related scientific information for the research community including: Most authoritative collection of substance information available Worldwide coverage of current and comprehensive journals and patents Chemical Abstracts Service, CAS

5. 2006 Edition

8. SciFinder content CAplus from CAS with 27.6 mil references, abstracts and detailed indexing from 1907- –Sources: 9,500 journals, patents from 50 offices, internet journals and preprint servers, conferences, theses and report –Citations from journals and patents 1997- Registry from CAS with ~88.5 mil substances –Small molecules, biosequences, polymers, inorganics, alloys, complexes –Single compounds have experimental data from InfoChem and CAS and have calculated data from ACDlabs

9. 2006 Edition SciFinder content CASREACT from CAS with 12.0 mil single and multi-step reactions –From journals and patents, 1907- ChemCats from CAS with supplier data from >955 catalogues –Screening compounds, fine chemicals and some bulk for 12 mil compounds Chemlist from CAS with regulatory information Medline from NLM with 16.5 mil records from 1950- –Sources: 3200 journals

10. 2006 Edition Unique and comprehensive databases: Creating Content

11. 2006 Edition Sample record (i)

12. 2006 Edition Sample record (ii)

13. 2006 Edition Sample record (iii)

14. 2006 Edition Sample record (v)

15. 2006 Edition Sample record in SciFinder Shows bibliographic details of the patent Includes patent family data The CAS abstract for this invention –much more informative than the original abstract Deep indexing of the relevant subjects and substances by CAS Registry numbers and their respective roles Examiner citation for this patent

16. 2006 Edition SciFinder functions Explore literature and patents by: –Substance name, formula or (sub)structure –Topic search with a natural language query –Author name or organization name –Reaction path or functional group transformation –BLAST search for biosequences –List of patent numbers –Specific bibliographic reference –Numerous ways to refine and analyze results Setting up alerts (Keep me Posted) Browse table of contents

17. 2006 Edition SciFinder: more than a search SciFinder has implemented several smart search processes to improve recall of relevant hits: –Research Topic Explore will use automatic searching of different spelling, word endings, word order and synonyms from a dictionary –Author Explore will provide candidates with similar spelling as provided –Structure Explore will automatically find tautomers and metal-containing complexes

18. 2006 Edition Full Text links to Chemport 374 Publishers –ACS –RSC –Academic Press –Springer Link –Am. Inst. Phys. –Highwire Publ. US Patent Office MicroPatent 6500+ Journals –Elsevier –Kluwer Acad. Publ. –Karger Publ. –Wiley –Marcel Dekker –Inst. of Physics EBSCO EPO’s Esp@cenet

19. 2006 Edition The true power of SciFinder SciFinder is the preferred research tool for scientists in industry and academia –Unmatched content and currency –Ease of use of the interface –Analysis tools that provide additional insights and creativity –Analysis tools that let the user handle larger answer sets effectively

20. 2006 Edition Analysis features for references

21. 2006 Edition Analysis features for references

22. 2006 Edition Analyze feature Good for analyzing basic document information, for instance –Analyze by most listed author –Analyze by publication year –Analyze by document type –Analyze by company/ organization name More convenient than Refine, since we see what is available in the answers –Find unexpected terms

23. 2006 Edition Categorize feature Very useful to organize indexing terms –Controlled terms for processes, biological entities, diseases, technologies, methods, etc. –Substance names in the context of their role in the documents List all catalysts, reactants, industrial manufactured compounds, compounds with therapeutic use

24. 2006 Edition Categorize on RC metathesis Reactants / Reagents

25. 2006 Edition Categorize on RC metathesis Catalysts

26. 2006 Edition Panorama feature Based on the same concept of organizing index terms in science categories Exports two categorize tables to Excel for cross-tabulation of terms Shows the number of references indexed with terms from the two categories –Choose them wisely to get the most out of Panorama’s data mining capabilities –SF2002 has some pre-worked Panorama sheets

27. 2006 Edition RC metathesis: Panorama of catalysts versus reactants/reagents Select different option from the drop down menus

28. 2006 Edition RC metathesis: Panorama of catalysts versus reactants/reagents

29. 2006 Edition RC metathesis: Panorama of catalysts versus reactants/reagents Allows you to identify main compounds in ring-closure metathesis reactions But also combinations that have few or no references Double-click a cell to get those references Click the charts button to create a variety of charts and trend lines Panorama sheet can be saved and re-used

30. 2006 Edition RC metathesis: Publication year trend lines for 5 catalysts

31. 2006 Edition SciFinder benefits Easy access to largest database covering chemistry and related sciences relevant to drug discovery –Solid look at IP status for substances and processes –Advanced analysis tools to handle larger answer sets in a creative way –Powerful alerting due to high currency of the information –Content and interface designed by scientists for scientists –Big time save not having to run experiments that are well documented in the literature –Big money save not having to continue projects that have already received patent protection by competition

32. 2006 Edition SciFinder for Govt Research Price structure based on a commitment in a 12 month period Access at a concurrent user level, each with a maximum number of individual users –1 ccu up to 40 users; 2 ccu up to 70 users –3 ccu up to 110 users; 5 ccu up to 200 users Pricing starts at $66,240 in 2007 –1 ccu $66,240; 2 ccu $106,200; 3 ccu $159,300; 5 ccu $265,500

33. 2006 Edition SciFinder Govt Research Usage restrictions –Sharing of loginids is not allowed –Not allowed to do searches for others –Not allowed to do searches for commercial research, including patentability searching –A scientist may not have more than 5,000 records saved on his/her PC –Inactivity timeout of 20 minutes Access can be limited by IP address

34. Questions?