1. 1 © Copyright 2008 EMC Corporation. All rights reserved. EMC Life Sciences Solutions

2. 2 © Copyright 2008 EMC Corporation. All rights reserved. Information Infrastructure 2005+ 2003-2005 Storage and Information Management Storage Company 1991-2002 2 EMC’s Evolution © Copyright 2008 EMC Corporation. All rights reserved.

3. 3 Approximately $4 Billion in Direct R&D – PLUS $7 Billion Invested in... EMC’s Investment in Developing Innovative Technology 3/031/041/051/061/07 Services Virtualization / Data Mobility Resource Management Content Management Availability / Archiving Information Security (Berkeley Data Systems)

4. 4 © Copyright 2008 EMC Corporation. All rights reserved. 2008 Top Pharmaceutical Industry Challenges, Trends, and Landscape*  More than 1/3 of life sciences organizations will increase overall IT spend by increase of 13%  35% expect to increase server and storage hardware spend by 14%  # 1 reason for IT budget increases is replacing outdated technology  Innovation remains key determinant of success or failure  Profitability highly correlated with quality of R&D procedures and speed of converting projects to viable products  Drop in number of “blockbusters” and ROI for new drugs driving significant shift to lower-cost, over-the-counter (OTC) products  Buying pipeline via strategic alliances and partnerships  Increased regulation of development and marketing  Secure, protect, and search intellectual property *Sources: Pharmaceutical Executive Magazine, Deloitte Consulting, Datamonitor, and IDC 4

5. 5 © Copyright 2008 EMC Corporation. All rights reserved. Current Priorities of Life Sciences CIOs  Manage information growth to speed cost-effective drug discovery and development  Consolidate IT resources and contribute to operating costs reductions  Information risk management – protect and secure intellectual property and other information assets  Streamline information workflows, increase collaboration, and improve content management processes  Replace/upgrade legacy systems with FDA validation  Achieve/maintain regulatory compliance – GxP, SAFE, FDA 21CFR, Part 11, “Electronic Records and Signatures” 5

6. 6 © Copyright 2008 EMC Corporation. All rights reserved. 25 of top 25 Pharmaceutical Companies Leverage EMC Infrastructure  Store more effectively  Backup, recovery, and archiving for regulated environments  Business continuity  Securing critical assets  Virtualization  Data center consolidation  High-performance computing  Enterprise content management  Manufacturing solutions with SAP  BusinessEdge life sciences consulting services Addressing CIOs Priorities with EMC Life Sciences Solutions 6

7. 7 © Copyright 2008 EMC Corporation. All rights reserved. Store Your Life Sciences Information More Effectively CLARiiON CX3 UltraScale Series AX4 InvistaEMC Centera EMC Centera Gen 4 LPNode Symmetrix DMX-4 and DMX-3 DMX-4 950 Celerra Rainfinity Global File Virtualization NSXNS80 NS20NS40GNS80G Connectrix Fibre Channel and iSCSI EMC Disk Library DL4400 DL210 DL4100 DL4200 DL4400 DL6000 NS40

8. 8 © Copyright 2008 EMC Corporation. All rights reserved. Backup, Recovery, and Archiving  Growing data volumes increase backup management time and complexity –Longer windows required for backup –Repeated backups of inactive content –Time-consuming, unreliable recovery –Demand for faster recovery times  EMC’s backup, recovery, and archiving solutions improve service levels and efficiency by speeding backup, recovery, and retrieval Business Challenges EMC Solutions  E-mail archiving solution  File system archiving solution  Backup-to-disk solution  Backup, recovery, and archiving assessment service

9. 9 © Copyright 2008 EMC Corporation. All rights reserved. Business Continuity  Improved availability and recovery service levels –More R&D and critical applications, such as e-mail –Downtime costs millions of dollars per hour or worse if patent window is missed  EMC expertise proven in thousands of customer deployments  Life sciences industry’s most comprehensive portfolio of local and remote recovery technologies Business Challenges EMC Business Continuity Solutions  Assess program/service levels  Evaluate availability and recovery alternatives  Design infrastructure  Conduct implementation planning  Test and implement technologies  Develop recovery/failover plans  Conduct recovery testing  Develop/update program definition  Manage resources, improvements, measurement

10. 10 © Copyright 2008 EMC Corporation. All rights reserved. EMC Security Solutions  Secure Enterprise Data  EMC Assessment for Storage Security  EMC Classification for Information Security  EMC Design and Implementation for Storage Encryption  Compliance and Security Information Management  Secure Customer Identities and Assets  Secure Remote Access  Secure Web Access  Secure Enterprise Access  EMC Certified Data Erasure Service  EMC Secure Remote Support Gateway Securing Critical Assets  Fewer than 1 in 5 life sciences organizations feel all their data is adequately protected  Need to manage, protect, and retrieve vital data throughout drug discovery lifecycle Business Challenges

11. 11 © Copyright 2008 EMC Corporation. All rights reserved. Assume They’re Already In Keep the Bad Guys Out Securing Critical Assets Threat Focus Approach Solution The Threat Profile Has Shifted Denial of service, network intrusion, external attack Access and availability Firewall, IPS/IDS, anti-malware Build and defend perimeters Privacy breach, intellectual property theft, insider attack Authorization and accountability Identity management, data encryption Manage and protect information

12. 12 © Copyright 2008 EMC Corporation. All rights reserved.  Secure People  Assess Risk  Secure Infrastructure  Secure Data  Assure Policy Compliance Securing Critical Assets Professional Security Services from EMC and Selected Partners  Assess the security of information to establish risk and priority Assess the security of information to establish risk and priority  Plan and implement information-centric security programs Plan and implement information-centric security programs Integrated IAM Solutions from EMC and Selected Partners  Assure and manage identity and control information access Assure and manage identity and control information access Information Infrastructure from EMC  Deliver inherently secure infrastructure with a common, integrated security platform Deliver inherently secure infrastructure with a common, integrated security platform Data Protection Solutions from EMC and Selected Partners  Discover, classify and directly protect sensitive information Discover, classify and directly protect sensitive information  Prevent online identity theft and fraud Prevent online identity theft and fraud Integrated SIEM Solutions from EMC and Selected Partners  Collect, correlate and analyze and manage security information in real time and over time Collect, correlate and analyze and manage security information in real time and over time Delivering Information-Centric Security

13. 13 © Copyright 2008 EMC Corporation. All rights reserved. Virtualization  Uncontrolled growth  Sprawling servers and storage  Underutilized IT assets  High costs and excessive downtime  Inflexible infrastructure Business Challenges EMC Virtualization Solutions  Server virtualization  Block storage virtualization  File storage virtualization  Infrastructure virtualization services

14. 14 © Copyright 2008 EMC Corporation. All rights reserved. Virtualization Virtualization Solutions Server Virtualization with VMware Infrastructure 3* Servers File Storage Virtualization with EMC Rainfinity Global File Virtualization IP network Global Namespace NAS STORAGE POOL File servers EMC NetApp Block Storage Virtualization with EMC Invista Invista Runs in the storage network Virtual volumes Physical storage

15. 15 © Copyright 2008 EMC Corporation. All rights reserved. Data Center Consolidation  Exceeding facility space and power capabilities  Proliferation of servers, storage; little rationalization or optimization  Concerns over cost of multiple data center locations  Relocation due to costs or disaster risk  Recent merger or acquisition 15 Business Challenges EMC Consolidation Solutions  Infrastructure strategy  Data center design and build  Migration discovery and analysis  Migration planning and implementation  Infrastructure deployment  Virtualization

16. 16 © Copyright 2008 EMC Corporation. All rights reserved. High Performance Computing  NAS request via IP –Standard NFS protocol used to request access to the file  Data delivery via iSCSI –Read/write operation performed directly between client and storage through the multi-protocol switch  Delivers high application performance –Transparent to applications –Sophisticated caching algorithms  Greater client scalability at lower cost –Cost-effective for thousands of grid computing nodes  Enhances Celerra scalability –Add Celerra MPFSi agent when additional performance is required Celerra MPFS for iSCSI (MPFSi) MPFS MPFSi Storage SAN NAS

17. 17 © Copyright 2008 EMC Corporation. All rights reserved. High Performance Computing  Business impact –Shortened data analysis time –Improved data availability and backups –Leverages low-cost Linux blades –No changes to applications MPFSi Application Example: Data-Mining Grid Celerra NSX Connectrix MDS switch Disk Library CLARiiON IP switch Linux blades

18. 18 © Copyright 2008 EMC Corporation. All rights reserved. Enterprise Content Management Solutions for Life Sciences Process Examples R&D collaboration Formulation management Protocol/methods management Content Examples Disease condition research Lead compounds Discovery and Research Process Examples Clinical trials planning CRO/investigator management eTrial master file Content Examples Preclinical results Study definitions Analysis and findings IND submissions Preclinical Process Examples eCTD – regulatory submissions Studies management eCase report form Content Examples NDA submission Study tagging files Trial materials Trial results Clinical Process Examples Batch content management Structured product labeling – PIM CAPA SOP management Content Examples GMP manufacturing and quality management Labeling Manufactur ing Process Examples Contracts management Marketing resource management Web content management Content Examples Promo materials Packaging Web site content Sales, Marketing, and Service

19. 19 © Copyright 2008 EMC Corporation. All rights reserved. COMPLIANCE INTERFACE Content Services Process Services Repository Services Workflow Relation & Link Management Transformations & Renditions XML Management Content Publishing Library Services Classification Categorization Lifecycles Portal Enterprise Search Enterprise Applications Collaborative Workplaces Regulatory Publishing Regulated Content Authoring Tool Integration Records Management Retention Policies Storage Optimization Change Control Auditing & Reporting Archiving Information Rights Mgmt. Security eSignatures SAFE Credentialing Access Control & Encryption Audit Trail Enterprise Content Management Templates Best Practices Process Discovery Modeling & Simulation Analysis & Optimization Forms Design Queue Management Systems Integration Process Execution Activity Monitoring

20. 20 © Copyright 2008 EMC Corporation. All rights reserved. COMPLIANCE IN A BOX Enterprise Content Management  Accelerate regulatory cycles and product commercialization  Develop standard operating procedures  Manage regulated content  Track clinical trials Regulated Content Management Comprehensive service offering targeting small-to- medium customers with regulatory needs Offered through EMC Documentum Partners Documentum Compliance Manager in a Box- 5 + user system Installed on an Intel server

21. 21 © Copyright 2008 EMC Corporation. All rights reserved. Manufacturing Solutions with SAP Key Milestones in EMC and SAP Partnership 1996 EMC/SAP launch corporate partnership 1997 Technology Partnership Agreement 1998 Worldwide Customer Support Agreement EMC Technology Center opens in Walldorf First Documentum integration released 1999 Technology Partner Plan developed 2000 SAP becomes EMC Development Partner 2001 EMC smooth transition to mySAP.com 2002 Initial Data Load Impact Minimized for SAP Business Warehouse 2003 EMC supports SAP Federated Databases EMC Replication Accelerators for SAP 2004 SAP supports VMware on Linux EMC Content Management and Archiving for SAP 2005 EMC named charter member of SAP “Titans of Technology” SAP Adaptive Certificate of Conformity with DELL EMC supports SAP NA Service Select program EMC Documentum Product portfolio support for SAP 2006 EMC joins SAP Enterprise Services Community SAP Adaptive Certificate of Conformity with Egenera on Windows 2007 EMC and FSC introduce BI Accelerator for SAP SAP Adaptive Certificate of Conformity with Linux, AIX RSA named member of SAP Global Security Alliance More than 5,000 joint customers 10 years of successful partnering 20 joint engineering projects yielding best practices

22. 22 © Copyright 2008 EMC Corporation. All rights reserved. Manufacturing Solutions with SAP EMC Delivery Model for SAP Store Protect Optimize Leverage ManageBuildPlan Customer Outcome Lower TCO Reduce risk Productivity Improve skills and service levels Achieve compliance Raise availability Augment staff END-TO-END TRANSFORMATION RESIDENCIES ARCHIVING DOCUMENT MANAGEMENT AUTOMATED SYSTEM CLONING INFORMATION SECURITY DATA PROTECTION VIRTUALIZATION AND TIERED STORAGE BUSINESS CONTINUITY AND DISASTER RECOVERY

23. 23 © Copyright 2008 EMC Corporation. All rights reserved. Product Development Speeding the right products to market, through process excellence and technology innovation Commercialization Improving commercial performance and delivery of brand objectives through marketing and sales effectiveness, productivity, integration and innovation Supply Chain Optimizing supply chain and manufacturing operations by increasing performance and productivity while reducing costs Contracts Management Providing companies secure enterprise- wide visibility into contractual obligations and liabilities, and improved compliance with regulations Compliance Management Managing compliance risk to maximize business value Life Sciences Consulting Services with BusinessEdge BusinessEdge Solutions areas of Expertise Client Initiatives Investigator selection analytics Pilot new selling models Digital asset and knowledge management Contract lifecycle management solutions Safety warehouse and analytics Legal spend management Client Impact Improve patient enrollment Access to physicians Effective touchpoint strategy Contract and rebate compliance Pharmacovigilance Outside legal spend Trends Expedite clinical trials Physician quality of life Multi-channel marketing Government and managed care reimbursement Public safety and trust Product and IP litigation