1. Open Notebook Science using Blogs and Wikis Jean-Claude Bradley E-Learning Coordinator College of Arts and Sciences Drexel University March 27, 2007 American Chemical Society Symposium on Communicating Chemistry

2. Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) CLOSED OPEN

3. Where is Science headed? WE ARE HERE

4. The Robot Scientist

5. How will this happen? Self-organizing redundant processes Self-organizing redundant processes Agents can participate with zero or near-zero cost (free hosted services – e.g. Google) Agents can participate with zero or near-zero cost (free hosted services – e.g. Google) Fully Open Access (Read and Write) Fully Open Access (Read and Write) Publication of all aspects of the scientific process: Open Source Science / Open Notebook Science Publication of all aspects of the scientific process: Open Source Science / Open Notebook Science Using semantically rich formats and automation at zero publication cost – is this the way to the technological singularity? Using semantically rich formats and automation at zero publication cost – is this the way to the technological singularity?

6. How can machines know what is important? Ask the humans

7. UsefulChem Blog

8. What chemists think is important in 2005

9. Find-A-Drug

10. Diketopiperazine Library Evolves to: on pot Ugi reaction/cyclization First iteration: Solid Support Synthesis

11. The Molecules Blog

12. The Experiments Blog

13. Comments from peers

14. The UsefulChem Wiki

15. Telling the story of the failures

16. Experiments moved to wiki

17. Experiment History

18. Experiment Edits

19. Third Party Time-Stamp on Experiment Versions

20. Monitoring experimental progress

21. How are people finding our experiments?

22. Molecules found by InChI

23. usefulchem.blogspot.com The blog as an integrative tool

24. usefulchem.wikispaces.com/Exp049 The wiki as the laboratory notebook

25. Open science connectivity More info on open source science here http://usefulchem.wikispaces.com

26. Automation in UsefulChem

27. CMLRSS feed on Bioclipse

28. Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp070 (48h 7 min)

29. Using ExcelVBA to automate kinetics analysis

30. Specify NMR regions and internal standard

31. NMR spectra of monitoring samples calculated

32. Reaction profile plotted automatically

33. UsefulChem in Second Life

34. Display blog post as poster

35. Click on Images for Descriptions

36. Click on the Blue Obelisk for a Chemistry Quiz Thanks Beth and Eloise!

37. neurodatabase.org Raw Experimental Data

38. Selected Experiments (some failed) Orgprepdaily.wordpress.com

39. Orgprepdaily.wordpress.com Vendor Reliability

40. Generalized Protocols Openwetware.org

41. Lab Notebook for intra-group communication Openwetware.org

42. Discussing Hypotheses RRResearch.blogspot.com

43. Feedback for the Automation Component Also – Rich Apodaca, Christoph Steinbeck, Peter Murray-Rust