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2. Be healthy for longer Be free from Health Problems Give Children a Good Start Consumer life goals re food

3. Huge global issues in nutrition 4bn people affected by malnutrition deserve the chance to develop physically & mentally to get more out of life. 50% of world’s population have blood cholesterol that’s too high. 30% of world’s population have blood pressure that’s too high.

4. Trends in society; The other side of the coin  Ageing population  Changes in lifestyle and dietary patterns have increased the incidence of chronic non-communicable diseases including –Obesity –Cardiovascular diseases –Hypertension –Diabetes mellitus –Certain cancers

5. Population numbers Healthy Unhealthy Target population for pharma industries Target population for food industries & public healthcare Green MR and van der Ouderaa F, Nature Pharmacogenomics - 2003 A vision for improving population health

6. ETP Food for Life Vision An effective integration of strategically-focussed, trans-national, concerted research in the nutritional-, food- and consumer sciences and food chain management will deliver innovative, novel and improved food products for, and to, national, regional and global markets in line with consumer needs and expectations. These products, together with recommended changes in dietary regimes and lifestyles, will have a positive impact on public health and overall quality of life (‘adding life to years’). Such targeted activities will support a successful and competitive pan- European agro-food industry having global business leadership securely based on economic growth, technology transfer, sustainable food production and consumer confidence.

7. ETP Food for Life Vision An effective integration of strategically-focussed, trans-national, concerted research in the nutritional-, food- and consumer sciences and food chain management will deliver innovative, novel and improved food products for, and to, national, regional and global markets in line with consumer needs and expectations. These products, together with recommended changes in dietary regimes and lifestyles, will have a positive impact on public health and overall quality of life (‘adding life to years’). Such targeted activities will support a successful and competitive pan- European agro-food industry having global business leadership securely based on economic growth, technology transfer, sustainable food production and consumer confidence.

8. European Technology Platform Food for Life - Food Quality & Manu- facturing Food & Health Food Safety Sustainable Food Production Food & Consumer Communication, Training & Technology Transfer Food Chain Management

9. Stakeholders’ proposal for a Strategic Research Agenda April, 2006

10. The key innovation challenges  The development of this ETP has been driven by the activities of its eight Working Groups  To optimize the synergy of its internal interactions, the Stakeholders’ Strategic Research Agenda, SSRA, has been drafted according to the seven Key Challenges for Innovation facing the European agri- food sector  These Challenges map closely with the goals and deliverables of the individual Working Groups

11. Well-being/ appearance Age Add life to years Healthy ageing: Goal

12. Food & Health Delivering a healthy diet Working group:  Prof Wim Saris, DMS & Univ Maastricht, NL (chair)  Dr Jacqueline Castenmiller, WCFS, NL (fascilitator)  Prof Nils-Georg Asp, LU, SE  Prof Robert-Jan Brummer, WCFS, NL  Dr Irene Corthesy, CRN, Nestlé, CH  Prof Hannelore Daniel, Techn Univ, München, D  Dr Gerd Hazer, Kraft, D  Dr Ian Johnson, IFR, Norwich, UK  Prof Bertold Koletzko, Univ München, D  Prof Ian Macdonald, Univ Nottingham,UK  Dr Gert Meijer, Unilever, NL  Dr Moïse Riboh, Danone, F

13. METABOLIC FUNCTIONS IMMUNE- & INTESTINAL FUNCTIONS BRAIN FUNCTIONS INFANT ELDERLY life-stage Food & Health: priority research areas

14. How did we work?  TOWARDS A STRATEGIC RESEARCH AGENDA FOR FOOD, NUTRITION & HEALTH 1.Please define research questions for each cell in the table. 2.For each of the research questions, describe: –-(Knowledge) deliverables; –-When to reach these deliverables: 2010, 2015 or 2020; –-Bottlenecks to solve the research questions; –-The breakthrough potential on a scale from 1 to 5 (low to high potential)? This is about the potential of the research to contributing to breakthrough chances or opening up new horizons for application-inspired research.

15. How did we work? 2  Table. Scientific targets Life cycleMetabolic function Immune functionBrain function Cell plasticity In-utero, new- borns, infants and young children -To optimise development 1 -Early disease prevention – minimising risk for later life 2 -Physical activity 3 -Programming and imprinting 4 -Optimal weaning foods to maximise resistance and to minimise food allergy 5 -Immune tolerance 6 -Nutrition and cognitive function 7 -Brain conditioning (e.g., taste perception) 8

16. How did we work 3

17. Food & Health Delivering a healthy diet  Understanding brain function in relation to diet  Understanding dietary effects on immune and intestinal function  Understanding the link between diet and metabolic function (obesity and associated metabolic disorders)  Understanding consumer behaviour in relation to health and nutrition

18. Goal 1: Understanding brain function in relation to diet  Diet and cognitive functions  Brain conditioning  Mood and optimal performance  Prevention of cognitive decline  Food intake regulation and hunger/satiety  Nutrition and interorgan signalling - esp gut-central nervous system interaction

19. Goal 2 Understanding dietary effects on immune and intestinal function  Modify systemic inflammatory activity by diet  Dietary factors that improve barrier functions  Biomarkers for intestinal health  Diet before and during pregnancy and lactation - immunefunction and allergy  Improved allergome database for foods

20. Goal 3 Understanding the link between diet and metabolic function (obesity and associated metabolic disorders  Early biomarkers of metabolic syndrome  Individual variations in metabolic energy efficiency  Food components that regulate food intake and increase termogenesis  Intervention strategies  Counteract age-associated muscle wasting  Low-grade inflammation - obesity/insulin resistance/metabolic syndrome  Epigenetic events - chronic disease  Maternal and infant recommendations for opt health  Meal composition and size - energy uptake, satiety

21. Goal 4 Understanding consumer behaviour in relation to health and nutrition  Key determinants of food habits  Biological determinants in food choice  Methodology to understand and quantify determinants  Perception and determinants of ”healthy lifestyle”  Better tools for effective communication  Consumer knowledge - consumer understanding of health schemes, health claims, simplified labelling - and personalised nutrition based on nutrigenomics

22. Low health costs Healthy ageing Improved education on healthy life style Extend higher education programmes along food- health chain Measures of trust Improved communication about food and health issues Involve SMEs in food and health area Premium taste and pleasure Low salt, low fat foods Improved packaging Personalised foods Increased intestinal and bone health Improved immune and cognitive functions Life style foods for each life cycle Age-related disease prevention Nutritional systems biology New measures for food intake and delivery systems New imaging and minimally invasive techniques Link databases and datamining of (non) food components, intake and health parameters Intestinal microbiota function and metagenomics Consumer preference, acceptance and needs societal needs consumers needs science needs The integrated picture

23. Horizontal Activities The role of Horizontal Activities is to optimise the impact of the ETP through:  Ensuring internal complementarity: Minimising gaps or duplication across the SRA  Establishing effective links with nationally- and FP6- funded projects, and other ETPs Maximising the effectiveness of European food chain science  Establishing the Mirror Group: Effecting a dialogue with national funding bodies, policy makers and opinion formers, COST, EUREKA, ESF etc  Promoting the ETP: Gaining the support of all European stakeholders  Organising national and regional consultations: Ensuring that the SRA addresses the needs and opportunities of all of Europe  Developing Scenario Studies Raising awareness of long-term challenges and opportunities for the food chain.

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