1. Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno and Ikue Mori

2. Background Worms will migrate to cultivation temperature when on a temperature gradient (H&R, 1975) Worm will avoid temperatures paired with starvation If E. coli paired with new temperature, take 2-4 hours before worms will migrate to the new temperature

3. Neural circuit Mori 1995

4. 25˚C 15˚C Thermotaxis Phenotypes Isothermic Themophilic Cryophilic Athermotactic N2 aho-2 hen-1 No ablation ttx-3 nsc-1 AFD/AIY ablation lin-11 AIZ ablation tax-2 tax-4 sel-12 RIA ablation 25˚C 15˚C 25˚C 15˚C 25˚C 15˚C

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18. Conclusions Respond differently to changes in temperature vs. feeding state aho-2 defective thermotactic avoidance