1. THE IMMUNE SYSTEM The InvadersThe Defender

2. AntibodiesCytokinesComplementInflammatory mediators COMPONENTS OF THE IMMUNE SYSTEM Cellular components of the immune system Soluble mediators of the immune system Lymphocytes Phagocytes Granulocytes Large granular lymphocyte T-cell B-cellMononuclear phagocyte Neurtrophil Eosinophil Basophil Mast cell Platelets Others

3. ORIGINATION OF CELLULAR COMPONENTS Pluripotent Stem cell Myeloid Stem cell Lymphoid stem cell MonocyteNeutrophil Macrophage PlateletsEosinophilBasophilMast cell B-cellT-cellPlasma cell Natural killer cell

4. THE EVOLUTION OF IMMUNITY Immunity Innate immunityAcquired immunity Non-specificSpecificImmediate onsetDelay onset Humoral Immune Response Cellular Immune Response Antibodies production T-cell activation

5. INNATE IMMUNITY 1 st Line Defense 2 nd Line Defense Pathogenic invasionBacteriaViruses SkinCiliated cellsLysozymeCoughing Blood clotMast cellCytokines Vomitting Leukocytes

6. THE INFLAMMATORY RESPONSE Capillary widening Increased blood flow Increased capillary permeability Release of fluid Leukocyte attraction Leukocytic migration Systemic response Leukocytic proliferation Heat, Redness, Tenderness, Swelling, Pain Tissue injury caused by pathogenic invasion

7. THE COMPLEMENT CASCADE The Complement System Mannose bindingAntibody binding OpsonizationInflammationCytolysis Classical Alternative

8. ACQUIRED IMMUNITY B-Cell Activation Cytotoxic T-Cell Activation Humoral Immunity Cell-mediated Immunity Antibodies Production Cell lysis Cytokines Activated T H cell

9. ATTRIBUTES OF ACQUIRED IMMUNITY Immunological Specificity Immunological Tolerance APC Receptor B-cell Plasma cell Memory B-cell Mature T-cell Memory T-cell Activated T-cell Immunological memory

10. THE MHC PROTEINS: CLASS I

11. THE MHC PROTEIN: CLASS II

12. RECOGNITION OF CLASS I MHC PROTEIN

13. RECOGNITION OF CLASS II MHC PROTEIN