1. Introduction to the Knowledge Discovery Department Institute for Infocomm Research Limsoon Wong Deputy Executive Director (Research) I 2 R: Imagination to reality

2. I2RI2R mission: Advance Infocomm Technology to benefit humanity and create prosperity for S’pore core values: Dedication to excellence, passion for innovation, integrity & respect size: 350 RSEs SERCBMRC IHPC DSI IMRE SIMTECH IME ICES

3. EDB-iDA ICT Cluster Map

4. Next Gen IP End-to-end QoS Mobile Middleware Mobile Adhoc Networks Mobile Sensor Networks Organization I2RI2R Communications & DevicesServices & ApplicationsMedia Processing Human Computer Interaction Media Semantics Infocomm Security E-Service Infrastructure Knowledge Discovery Radio SystemsNetworkingLightwaveEmbedded Systems Digital Wireless Mutimedia Signal Processing Noise Reduction Media Adaptation Mixed Media Mining Natural Language Synergy Pervasive Media Perceptual Human Media Speech & Dialogue Biometrics Cryptography Network security Information security Service Composition Service creation Data-in-Network Connected Home Secure Filesystem/ DBMS Modem Technology Multiple Access Smart Antenna Array Systems Network Design WDM Systems Fibre Technology Terminal Software Defined Radio Transceiver system Antenna Radio Over Fiber UWB Knowledge Extraction Decision Systems Discovery Systems

5. Information Security E-services Infrastructure Knowledge Discovery Services & Applications Knowledge Extraction Data fusion from sensors, knowledge extraction technologies. Applications in functional genomics & gene regulatory networks Decision Systems Data Mining technologies. Applications in clinical data analysis and protein network analysis Discovery Systems Data cleansing, modeling & knowledge management technologies. Applications in immunoinformatics and venominformatics Service Creation Policy-based framework for creating/managing application, storage and network services Data-in-Network High-speed data cache and IPC on optical network Service Composition Tech for consumers to create personalized services from component e- services Connected Home Reference design for an OSGi compliant residential gateway Cryptography Cryptographic techniques for privacy protection, high- speed encryption, group digital signatures and new public key infrastructure Information Security Techniques for privacy protection, peer-to-peer system security and media security Network Security Wireless network security, intrusion detection and technology to trace attackers Secure Filesystem Steganographic and reliable file systems/DBMSs on externally managed platforms

6. Integration Technology (Kleisli) Cleansing & Warehousing (FIMM) MHC-Peptide Binding (PREDICT) Protein Interactions Extraction (PIES) Gene Expression & Medical Record Datamining (PCL) Gene Feature Recognition (Dragon) Venom Informatics 1994 19981996 2000 2002 8 years of bioinformatics R&D in Singapore ISS KRDL LIT/I 2 R GeneticXchange Molecular Connections Biobase History

7. Directions Knowledge Extraction gene regulatory network endocrinology info system Discovery Systems immunoinformatics venominformatics Decision Systems clinical data analysis protein interaction network Technologies for data mining data fusion data cleansing data modeling knowledge extraction knowledge management Advance data mining technologies in decision systems for complex problems Translate inspiration from biological systems into advancement in life and computing sciences

8. Decision Systems Lab Highlight PCL Technology Machine learning of emerging patterns Rules learned by computers easily understood by doctors High accuracy Yeoh et al. Cancer Cell 1, 133-143, 2002

9. FANTOM2 Consortium Nature 420, 563-573, 2002 Discovery Systems Lab Highlight Brusic et al. Cytokine- related genes identi- fied from the RIKEN full-length mouse cDNA dataset. Genome Res. (in press) Silva et al. Identifica- tion of novel human disease-related gene candidates from the RIKEN full-length mouse cDNA dataset. Genome Res. (in press)

10. KE Lab Highlight Dragon Promoter Finder and Dragon Gene Start Finder Very high accuracy, order of magnitude improvement Licensed to Biobase, integrated with TRANSPLORER and TRANSFAC

11. Qualification 18 full-time staff (9 PhD, 6MSc, and 3 BSc) and 10-20 students at any time Our faculty holds adjunct professorial positions (SANBI, Univ. of Canberra, NUS, and NTU) During the last two years 8 MSc students graduated under our supervision

12. Professional Activities Journals: 3 chief editorial roles, and 9 editorial board memberships International Conferences (last 5 years): 4 conference chairs, and more than 40 program committee roles, 10 keynote lectures, and dozens of plenary talks

13. Track Record Publications (last 5 years): More than 100 in last 5 years, many in top journals (e.g. Nature, PNAS, Cancer Cell, JACM) and top conferences. Patents (last 5 years): 1 granted and 6 pending Commercialization (last 5 years): 2 international start-ups and one software licensed

14. People Decision Systems Head: Dr. See-Kiong Ng PI: A/Prof. Limsoon Wong, Dr. Jinyan Li Staff:Huiqing Liu, Zhuo Zhang, Soon-Heng Tan Post Doc: Dr. Shaowu Meng Discovery Systems Head:A/Prof. Vladimir Brusic Staff:Judice Koh, Guanglan Zhang, Seng Hong Seah Post Doc: Dr. Rekha Pillai Knowledge Extraction Head: Prof. Vladimir B. Bajic Staff:Hao Han, SPT Krishnan, Allen Chong, Sin Lam Tan Post Doc:Dr. Suisheng Tang

15. Here they are...